Results 191 to 200 of about 45,036 (321)

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

open access: yesAllergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng   +20 more
wiley   +1 more source

Contact sensitisers activate keratinocytes and induce cytotoxicity via Transient Receptor Potential Ankyrin 1 in allergic contact dermatitis

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber   +8 more
wiley   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

open access: yesCell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang   +12 more
wiley   +1 more source

Quantum-noise randomized data encryption for wavelength-division-multiplexed fiber-optic networks [PDF]

open access: green, 2005
Eric Corndorf   +4 more
openalex   +1 more source

The “Tianyu” Formulation Alleviates Rheumatoid Arthritis by Modulating the NLRP3/Caspase‐1/GSDMD‐Mediated Pyroptosis Pathway

open access: yesThe FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Proposed signaling pathway by which TY modulates NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis. ABSTRACT This research focuses on exploring the modulation of pyroptosis and its underlying mechanisms via the “Tianyu” formulation (TY), a traditional Chinese medicine, in human rheumatoid arthritis fibroblast‐like synovial cells (RA‐HFLS) and a collagen ...
Yueya Zhu   +5 more
wiley   +1 more source

Lithium Niobate Quadratic Integrated Nonlinear Photonics: Enabling Ultra‐Wide Bandwidth and Ultrafast Photonic Engines

open access: yesNanophotonics, Volume 15, Issue 9, 13 May 2026.
This perspective surveys emerging quantum and classical photonic applications across operating wavelengths and timescales, highlighting persistent technological gaps in integrated light sources. We examine the unique advantages of quadratic nonlinear photonics on the thin‐film lithium niobate (TFLN) platform and discuss strategies for realizing ...
Meng Tian   +7 more
wiley   +1 more source

Terahertz Metasurface for Spatial Detection of Full Stokes Parameters and Polarization Imaging

open access: yesNanophotonics, Volume 15, Issue 9, 13 May 2026.
This work presents a THz polarization analyzer with significantly improved robustness against nonuniformity. By integrating four polarization‐sensitive meta‐atoms into a meta‐cell, the metalens splits incident light into six polarization components and generates off‐axis focal spots.
Shengnan Guan   +5 more
wiley   +1 more source

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