Results 281 to 290 of about 140,939 (365)

Microfluidic single‐cell technologies for immunotherapeutic target discovery: From design concepts to preclinical applications

VIEW, EarlyView.
Immunotherapy leverages the immune system to treat cancer and autoimmune diseases but is hindered by cellular heterogeneity in tissues and immune landscapes. Single‐cell technologies, particularly microfluidic‐enabled omics, revolutionize disease understanding by resolving this complexity at unprecedented resolution.
Haopu Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Scaling up for end-to-end on-chip photonic neural network inference. [PDF]

Light Sci Appl
Wu B, Huang C, Zhang J, Zhou H, Wang Y, Dong J, Zhang X.   +6 more
europepmc   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Creation of Low-Loss Triple-Ring Optical Filter via Direct Binary Search Inverse Design. [PDF]

Sensors (Basel)
Hu Y, Wang T, Zhou W, Hu B.
europepmc   +1 more source

Deciphering the Immunomodulatory Function of GSN+ Inflammatory Cancer‐Associated Fibroblasts in Renal Cell Carcinoma Immunotherapy: Insights From Pan‐Cancer Single‐Cell Landscape and Spatial Transcriptomics Analysis

Cell Proliferation, EarlyView.
Pan‐cancer scRNA‐seq and ST‐seq analyses identify GSN+ inflammatory cancer‐associated fibroblasts (CAFs) and their spatial distribution in immune checkpoint inhibitor (ICI) therapy. The Caf.Sig model accurately predicts ICI response across cancers using CAF gene signatures and machine learning.
Shan Li, Xinwei Zhou, Haoqian Feng, Kangbo Huang, Minyu Chen, Mingjie Lin, Hansen Lin, Zebing Deng, Yuhang Chen, Wuyuan Liao, Zhengkun Zhang, Jinwei Chen, Bohong Guan, Tian Su, Zihao Feng, Guannan Shu, Anze Yu, Yihui Pan, Liangmin Fu   +18 more
wiley   +1 more source

High-performance achromatic flat lens by multiplexing meta-atoms on a stepwise phase dispersion compensation layer. [PDF]

Light Sci Appl
Lin J, Chen J, Zhang J, Liang H, Li J, Wang XH.   +5 more
europepmc   +1 more source

Quantitative analysis of human umbilical vein endothelial cell morphology and tubulogenesis

Journal of Microscopy, EarlyView.
Abstract Primary human umbilical vein endothelial cells can grow as both a monolayer in culture and also as a capillary‐like network making them an ideal model system in order to study vascular remodelling. Image‐based analysis can allow assessment of cell morphology and motility but is dependent on accurate cell segmentation which requires high ...
Viviane Mignone, Maria Augusta Arruda, Laura Kilpatrick, Benjamin Moore, Jeanette Woolard, Stephen Hill, Joëlle Goulding   +6 more
wiley   +1 more source

Energy efficient traffic data aggregation and routing for metropolitan optical access network. [PDF]

Sci Rep
Kumar TS, V M, Senthilkumar S.
europepmc   +1 more source

Fourier ptychography microscopy for digital pathology

Journal of Microscopy, EarlyView.
Abstract Fourier ptychography microscopy (FPM) has made significant progress since its invention in 2013, thanks to its adaptable nature, high resolution, and vast field‐of‐view capabilities. FPM is used in various medical applications across multiple optical wavelengths, from automated digital pathology to radiology and ultraviolet label‐free imaging.
Fraser Eadie, Laura Copeland, Giuseppe Di Caprio, Gail McConnell, Akhil Kallepalli   +4 more
wiley   +1 more source