Results 61 to 70 of about 1,516,944 (293)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Determination of the Most Effective Wavelengths for Prediction of Fuji Apple Starch and Total Soluble Solids Properties

Applied Sciences, 2020
Proper physical properties and standard chemical properties are among the criteria that consumers use to select fruits. Recently, researchers attempted to develop non-destructive methods for measuring properties, among which the near-infrared (NIR ...
Razieh Pourdarbani, Sajad Sabzi, Sanaz Jarolmasjed, Thomas Panagopoulos   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Waveguide sub‐wavelength structures: a review of principles and applications

, 2015
Periodic structures with a sub‐wavelength pitch have been known since Hertz conducted his first experiments on the polarization of electromagnetic waves.
R. Halir, P. Bock, P. Cheben, A. Ortega‐Moñux, C. Alonso‐Ramos, J. Schmid, J. Lapointe, Danxia Xu, J. Wangüemert-Pérez, Í. Molina‐Fernández, S. Janz   +10 more
semanticscholar   +1 more source

Quantum teleportation from a telecom-wavelength photon to a solid-state quantum memory [PDF]

Nature Photonics, 2014
Quantum teleportation of the state of a qubit encoded in the polarization state is demonstrated from a telecom-wavelength photon to a solid-state quantum memory via 24.8 km of optical fibre.
F. Bussières, C. Clausen, A. Tiranov, B. Korzh, V. Verma, S. Nam, F. Marsili, A. Ferrier, P. Goldner, H. Herrmann, C. Silberhorn, W. Sohler, M. Afzelius, N. Gisin   +13 more
semanticscholar   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Wavelength-multiplexed quantum networks with ultrafast frequency combs [PDF]

Nature Photonics, 2013
Highly entangled quantum networks (cluster states) lie at the heart of recent approaches to quantum computing1,2. Yet the current approach for constructing optical quantum networks does so one node at a time3,4,5, which lacks scalability.
J. Roslund, R. M. de Araújo, Shifeng Jiang, C. Fabre, N. Treps   +4 more
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

On Wavelength-Routed Networks With Reversible Wavelength Channels

Journal of Lightwave Technology, 2013
We observe that the performance of wavelength- routed (WR) networks often suffers from asymmetric traffic and network traffic patterns differing from the original design plans. WR networks with a fixed number of channels in a given transmission direction are inflexible. Therefore, we propose reversible wavelength channels.
Li, CY, Wai, PKA, Li, VOK
openaire   +3 more sources