Results 31 to 40 of about 258,423 (283)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

An Online Monitoring Approach of Carbon Steel Corrosion via the Use of Electrochemical Noise and Wavelet Analysis

Metals
In this study, carbon steel was examined under different corrosive conditions using electrochemical noise (EN) as the primary method of investigation.
Ahmed Abdulmutaali, Yang Hou, Chris Aldrich, Katerina Lepkova   +3 more
doaj   +1 more source

Moduli of continuity of functions in Holder’s class by First kind Chebyshev Wavelets and Its Applications in the Solution of Lane-Emden Differential Equations

Ratio Mathematica, 2023
In this paper , two new moduli of continuityand two estimators E2k−1,0 and,E2k−1,M of a functions f in H¨older’s class Hα,2ωk [0, 1) by First kind Chebyshev Wavelets have been determined.
Shyam Lal, Deepak Kumar Singh
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Multi-scale investigation on streamflow temporal variability and its connection to global climate indices for unregulated rivers in India

Journal of Water and Climate Change, 2022
With the increasing stress on water resources for a developing country like India, it is pertinent to understand the dominant streamflow patterns for effective planning and management activities.
Pavan Kumar Yeditha, Tarun Pant, Maheswaran Rathinasamy, Ankit Agarwal   +3 more
doaj   +1 more source

Wavelet Analysis and Chirps

Applied and Computational Harmonic Analysis, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Meyer, Yves, Xu, Hong
openaire   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Wavelet Sets on Locally Compact Abelian Groups

پژوهش‌های ریاضی, 2020
Introduction An orthonormal wavelet is a square-integrable function whose translates and dilates form an orthonormal basis for the Hilbert space . That is, given the unitary operators of translation  for  and dilation , we call  an orthonormal wavelet if
Mehdi Rashidi-Kouchi
doaj