Results 101 to 110 of about 2,053 (246)

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Safety, Adherence and Attractiveness of Whole-Body Electromyostimulation in Non-Athletic Cohorts. A Systematic Review [PDF]

Objective: Whole-body electromyostimulation (WB-EMS) is considered as a time efficient training technology particular suitable to increase function, fitness and health-related outcome in people unable or unmotivated to exercise conventionally.
Kemmler, Wolfgang, Uder, Michael, von Stengel, Simon   +2 more
core   +1 more source

Eletroestimulação de corpo inteiro: uma breve revisão narrativa sobre seus benefícios e riscos/Whole-body electrostimulation: a brief narrative review of its benefits and risks [PDF]

, 2020
A eletroestimulação de corpo inteiro (WB-EMS, do inglês whole-body electromyostimulation) é uma técnica que vem se tornando mais popular em virtude de sua oferta cada vez mais frequente em academias e centros de fitness em muitos países, inclusive no ...
Barros, Bruna Massaroto, Bocalini, Danilo Sales, Evangelista, Alexandre Lopes, Evangelista, Alexandre Lopes, Gomes, Michelli Christian Soares Santos, Paunksnis, Marcos Rodolfo Ramos, Santos, Letícia Menezes, Souza, Cleison Rodrigues de, Teixeira, Cauê Vazquez La Scala   +8 more
core   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

Impact of whole body electromyostimulation on cardiometabolic risk factors in older women with sarcopenic obesity: the randomized controlled FORMOsA-sarcopenic obesity study

Clinical Interventions in Aging, 2016
Katharina Wittmann,1 Cornel Sieber,2 Simon von Stengel,1 Matthias Kohl,3 Ellen Freiberger,2 Franz Jakob,4 Michael Lell,5 Klaus Engelke,1 Wolfgang Kemmler1 1Institute of Medical Physics, Faculty of Medicine, Friedrich-Alexander University of Erlangen-N ...
Wittmann K, Sieber C, von Stengel S, Kohl M, Freiberger E, Jakob F, Lell M, Engelke K, Kemmler W   +8 more
doaj  

Efeito do treinamento de eletroestimulação neuromuscular de corpo inteiro para a melhora da saúde ao rendimento esportivo uma revisão [PDF]

, 2021
O treinamento de eletroestimulação neuromuscular de corpo inteiro (TEN-CI) é uma metodologia de treinamento relativamente recente no Brasil. No entanto, falta consenso sobre a eficácia do TEN-CI.
Espindola, Angelo Souza
core  

Pro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors

Advanced Science, EarlyView.
Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...
Xiaoling Xu, WeiYi Cheng, Menghang Yang, Li He, WeiYe Ren, JingQuan Chen, LiTing He, Dandan Bao, Zhihong Zhu, Lixin Wang, Qinghua Yao, Ji‐Gang Piao   +11 more
wiley   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Effects of whole-body electromyostimulation combined with individualized nutritional support on body composition in patients with advanced cancer: a controlled pilot trial

BMC Cancer, 2018
Background Physical exercise and nutritional treatment are promising measures to prevent muscle wasting that is frequently observed in advanced-stage cancer patients.
Kristin Schink, Hans J. Herrmann, Raphaela Schwappacher, Julia Meyer, Till Orlemann, Elisabeth Waldmann, Bernd Wullich, Andreas Kahlmeyer, Rainer Fietkau, Dorota Lubgan, Matthias W. Beckmann, Carolin Hack, Wolfgang Kemmler, Jürgen Siebler, Markus F. Neurath, Yurdagül Zopf   +15 more
doaj   +1 more source

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

Advanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie   +14 more
wiley   +1 more source