Results 201 to 210 of about 57,825 (235)

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source

Developmentally Guided Differentiation of Ventral Midbrain Dopaminergic Cells Validated in Proteopathy‐Based Parkinson's Disease Models

Advanced Science, EarlyView.
A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon, Heejeong Kim, Elliot H. Lee, Hanseul Kim, Ji Hun Kim, Huisu Jeong, Jiwon Cheon, Ga Ram Jeong, Byoung Dae Lee, Jae‐Won Cho, Soo‐Jin Oh, Yunjong Lee, Yohan Oh   +12 more
wiley   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

Dual Randomness From Spatial and Temporal Variations in Stochastic Zinc Gallate Nanoclusters for PUF and TRNG Co‐Driven Image Generation

Advanced Science, EarlyView.
A dual‐randomness hardware platform is demonstrated by integrating PUF and TRNG functionalities into mixed‐ZGO nanoclusters. By leveraging spatial and temporal stochasticity, the mixed‐ZGO NCs device enables both unique identification and random signal generation.
Seungme Kang, Wangmyung Choi, Jueun Lee, Yeong Kwon Kim, Byung Chul Jang, Wonjun Shin, Hocheon Yoo   +6 more
wiley   +1 more source

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2018
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WC-Co Versus Ticn/WC–Co, Ni For New Cutting Tools

Euro PM2023 Proceedings, 2023
Advanced cutting tools are required for the new challenge of the machining industry to make more sustainable solutions. Material extrusion (MEX), as an indirect additive manufacturing technology, could be used to process hardmetals (WC-Co) and, also, the designated cermets (TiCN/WC and Co, Ni).
Gonçalo Oliveira, Ricardo Mineiro, Ana Maria Rocha Senos, Cristina Fernandes, Daniel Figueiredo, Teresa Vieira Maria   +5 more
openaire   +1 more source

Grinding of WC–Co hardmetals

Wear, 2001
Morphol. of ground surface of WC-Co cermets with 10 and 20% Co was studied. A deformed and detached surface layer was found on top of the specimens after surface grinding with a diamond wheel. Etching the surface layer revealed WC grains in the subsurface of the machined specimens. Most of these grains were plastically deformed by prismatic slip in the
Hegeman, J.B J W, de Hosson, J.T.M., de With, G.   +2 more
openaire   +1 more source

Segregation of Vanadium at the WC/Co Interface in VC-doped WC-Co

Journal of Materials Research, 1998
Morphology of carbide grain in WC–12 wt.% Co–0.5 wt.% VC was examined by HREM and EDS with a special interest in the segregation of V at the WC/Co interfaces. A small addition of VC in WC-Co is effective to suppress the grain growth of carbide grains.
A. Jaroenworaluck, T. Yamamoto, Y. Ikuhara, T. Sakuma, T. Taniuchi, K. Okada, T. Tanase   +6 more
openaire   +1 more source

Friction and Wear Behaviors of WC-Co/WC-Co Pairs in Air

Materials Science Forum, 2007
To investigate sliding friction and wear behaviors of WC–Co/WC–Co pairs containing different WC grain sizes, the ball-on-disc test in air were carried out for WC-Co containing WC grain sizes of 0.5 μm (F.G.) and 1.5 μm (C.G.). The results show that the wear volume of F.G. pin for F.G. pin/C.G. disc is larger than that of F.G. pin for F.G. pin/F.G. disc
Hiroyuki Hosokawa, Takeshi Nakajima, Koji Shimojima   +2 more
openaire   +1 more source

Schleifen von WC-Co-Hartmetallen*/Grinding of Cemented Carbides (WC-Co)

wt Werkstattstechnik online, 2016
Beim Schleifen mehrphasiger Werkstoffe mit sprödhartem Charakter, beispielsweise Hartmetall, wurde ein Übergang von sprödhartem zu duktilem Werkstoffverhalten nachgewiesen. Der Fachartikel stellt eine neu entwickelte Methodik zur systematischen Analyse des Zerspanverhaltens – im Speziellen den Übergang von vorwiegend duktilem zu überwiegend sprödhartem
C. Wirtz, F. Vits, P. Mattfeld, F. Prof. Klocke   +3 more
openaire   +1 more source