Results 61 to 70 of about 11,603,293 (284)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Causation in the Presence of Weak Associations [PDF]
Critical Reviews in Food Science and Nutrition, 2010 Despite their observational nature, epidemiologic studies have been used to make inductive inferences about the causes of human diseases. In this context, I mainly consider the term “cause” in its cognitive (explanatory) meaning, that is, by detecting causal factors and identifying mechanisms of diseases.
openaire +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Qubit models of weak continuous measurements: markovian conditional and open-system dynamics [PDF]
, 2017 In this paper we approach the theory of continuous measurements and the associated unconditional and conditional (stochastic) master equations from the perspective of quantum information and quantum computing.
J. Gross +3 more
semanticscholar +1 more source
Acute neuromuscular weakness associated with dengue infection
Journal of Neurosciences in Rural Practice, 2012 ABSTRACT Background: Dengue infections may present with neurological complications. Whether these are due to neuromuscular disease or electrolyte imbalance is unclear. Materials and Methods: Eighty-eight patients of dengue fever required hospitalization during epidemic in year 2010.
Hira, Harmanjit Singh +2 more
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Grothendieck–Verdier duality patterns in quantum algebra
, 2017 After a brief survey of the basic definitions of the Grothendieck--Verdier categories and dualities, I consider in this context introduced earlier dualities in the categories of quadratic algebras and operads, largely motivated by the theory of quantum ...
Manin, Y.
core +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
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Weak association of random variables
Journal of Multivariate Analysis, 1981 AbstractThe dependence concept of weak association is introduced and is shown to be equivalent to positive quadrant dependence. Furthermore, a characterization of independence in the class of positive quadrant dependent random variables by means of moment conditions is proved.
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