Results 61 to 70 of about 1,349,480 (242)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
On weak and strong magnetohydrodynamic turbulence
, 2007 Recent numerical and observational studies contain conflicting reports on the spectrum of magnetohydrodynamic turbulence. In an attempt to clarify the issue we investigate anisotropic incompressible magnetohydrodynamic turbulence with a strong guide ...
Jean Carlos Perez +2 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The Effect of Quadriceps Weakness in Older Adults on Lower Extremity Muscle Function During Gait [PDF]
, 2015 Osteoarthritis is a painful condition that generally causes patients to experience weak quadriceps, abnormal gait kinematics, and difficulty completing daily movements.
Wetli, Alaine
core
Inhomogenized sudden future singularities
, 2005 We find that sudden future singularities may also appear in spatially inhomogeneous Stephani models of the universe. They are temporal pressure singularities and may appear independently of the spatial finite density singularities already known to exist ...
A. Krasiński +6 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Spin effects on charged particle motion in magnetized Reissner–Nordström spacetime
European Physical Journal C: Particles and FieldsThis study investigates the dynamics of spinning charged test particles in the spacetime of a Reissner–Nordström (RN) black hole immersed in an asymptotically uniform magnetic field, using the Mathisson–Papapetrou–Dixon (MPD) equations supplemented with ...
Tursinbay Oteev +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
پژوهان, 2016 Objective: Students Research Center tries to increase of efficiency and the development of educational and research. The basic requirement for quality assurance and process improvement research centers, evaluation can be used. Therefore, this study aimed
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doaj