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Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

open access: yesAdvanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj   +21 more
wiley   +1 more source

Weak Convergence to Extremal Processes

open access: yesThe Annals of Probability, 1975
$\{X_n, n\geqq 1\}$ are i.i.d. rv's with df $F$. Set $M_n = \max\{X_1, \cdots, X_n\}$. As a basic assumption, suppose normalizing constants $a_n > 0, b_n, n \geqq 1$ exist such that $\lim_{n\rightarrow\infty} P\lbrack M_n \leqq a_n x + b_n \rbrack = G(x)$, nondegenerate. Define the random function $Y_n(t) = (M_{\lbrack nt \rbrack} - b_n)/a_n$.
openaire   +2 more sources

Tailoring the Properties of Functional Materials With N‐Oxides

open access: yesAdvanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich   +5 more
wiley   +1 more source

Peptide Sequencing With Single Acid Resolution Using a Sub‐Nanometer Diameter Pore

open access: yesAdvanced Functional Materials, EarlyView.
To sequence a single molecule of Aβ1−42–sodium dodecyl sulfate (SDS), the aggregate is forced through a sub‐nanopore 0.4 nm in diameter spanning a 4.0 nm thick membrane. The figure is a visual molecular dynamics (VMD) snapshot depicting the translocation of Aβ1−42–SDS through the pore; only the peptide, the SDS, the Na+ (yellow/green) and Cl− (cyan ...
Apurba Paul   +8 more
wiley   +1 more source

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