Results 71 to 80 of about 1,749,039 (283)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Structural Features of Sequential Weak Measurements [PDF]

open access: yes, 2016
We discuss the abstract structure of sequential weak measurement (WM) of general observables. In all orders, the sequential WM correlations without post-selection yield the corresponding correlations of the Wigner function, offering direct quantum ...
Diósi, Lajo
core   +2 more sources

Weak measurements and nonClassical correlations [PDF]

open access: yesAnnals of Physics, 2017
We extend the definition of quantum discord as a quantifier of nonClassical correlations in a quantum state to the case where weak measurements are performed on subsystem $A$ of a bipartite system $AB$. The properties of weak discord are explored for several families of quantum states.
Lekshmi, S., Shaji, N., Shaji, Anil
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Non-statistical weak measurements [PDF]

open access: yesSPIE Proceedings, 2007
Non-statistical weak measurements yield weak values that are outside the range of eigenvalues and are not rare, suggesting that weak values are a property of every pre-and-post-selected ensemble. They also extend the applicability and valid regime of weak values.
Tollaksen, Jeff, Aharonov, Yakir
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Calibration biases in measurements of weak lensing

open access: yes, 2011
As recently shown by Viola et al., the common (KSB) method for measuring weak gravitational shear creates a non-linear relation between the measured and the true shear of objects. We investigate here what effect such a non-linear calibration relation may
B. M. Schäfer   +17 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Emergence of realism through quantum discord suppression in photonic weak measurements

open access: yesNew Journal of Physics
The emergence of realism from the quantum domain, often associated with the suppression of quantum features, is a key aspect of the quantum-to-classical transition.
Fabrício Lustosa   +5 more
doaj   +1 more source

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