The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
Stochastic Resonance in an Underdamped System with Pinning Potential for Weak Signal Detection. [PDF]
Zhang H, He Q, Kong F.
europepmc +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Compound Fault Feature Extraction of Gearbox based on Improve Variational Mode Decomposition
In the practical condition,the fault signal of gearbox often contain multiple fault information,but the weak fault signal belongs to weak signal compared with strong fault signal and noise,therefore,the extraction of weak fault signal in complex fault is
Chai Huili, Ye Meitao, Wang Zhijian
doaj
Generalized Parameter-Adjusted Stochastic Resonance of Duffing Oscillator and Its Application to Weak-Signal Detection. [PDF]
Lai ZH, Leng YG.
europepmc +1 more source
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
High-Fidelity Weak Signal Extraction for Coiled Tubing Acoustic Telemetry via Micro-Lever Suspension and Joint Denoising. [PDF]
Xie Y +5 more
europepmc +1 more source
Optimization of weak signal propagation in a feedforward network [PDF]
Uzuntarla M, Ozer M, Koklukaya E.
europepmc +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Weak signal extraction enabled by deep neural network denoising of diffraction data. [PDF]
Oppliger J +22 more
europepmc +1 more source

