Results 51 to 60 of about 1,205,866 (291)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Weak signals and wild cards in water and sanitation services – exploring an approach for water utilities

European Journal of Futures Research, 2017
Weak signals and wild cards are used to scan the environment and make systems more sensitive to emerging changes. In this paper, the applicability of weak signals and wild cards is experimented in a case of a highly reliable and conservative sector ...
Annina Takala, Ossi Heino
doaj   +1 more source

Sampling and Reconstruction of Graph Signals via Weak Submodularity and Semidefinite Relaxation

, 2017
We study the problem of sampling a bandlimited graph signal in the presence of noise, where the objective is to select a node subset of prescribed cardinality that minimizes the signal reconstruction mean squared error (MSE).
Hashemi, Abolfazl, Mateos, Gonzalo, Shafipour, Rasoul, Vikalo, Haris   +3 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Lepton energy moments in semileptonic charm decays

, 2010
We search for signals of Weak Annihilation in inclusive semileptonic D decays. We consider both the widths and the lepton energy moments, which are quite sensitive probes. Our analysis of Cleo data shows no clear evidence of Weak Annihilation, and allows
Allison, Amsler, Antonelli, Aquila, Asner, Asner, Baek, Bazavov, Becirevic, Becirevic, Bigi, Bigi, Bigi, Bigi, Bigi, Bigi, Bigi, Bigi, Bigi, Blok, Bona, Buchmuller, Chay, Cheng, Czarnecki, Dassinger, Di Pierro, Dikeman, Gambino, Gambino, Gambino, Gremm, Grinstein, Hoang, Jernej F. Kamenik, Kamenik, Leibovich, Ligeti, Lubicz, Manohar, Melnikov, Pak, Paolo Gambino, Pirjol, Uraltsev, Uraltsev, Voloshin   +46 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Two-qubit parametric amplifier: large amplification of weak signals

, 2012
Using numerical simulations, we show that two coupled qubits can amplify a weak signal about hundredfold. This can be achieved if the two qubits are biased simultaneously by this weak signal and a strong pump signal, both of which having frequencies ...
A. L. Rakhmanov, A. M. Zagoskin, A. M. Zagoskin, A. N. Omelyanchouk, A. Zagoskin, Franco Nori, G. Wendin, M. Le Bellac, P. Moin, S. Savel'ev, V. Damgov, Z. Washington   +11 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Weak values obtained from mass-energy equivalence

, 2017
Quantum weak measurement, measuring some observable quantities within the selected subensemble of the entire quantum ensemble, can produce many interesting results such as the superluminal phenomena.
Zhang, Miao
core   +1 more source