Results 131 to 140 of about 971,014 (304)

SPG4 and Dementia: Expanding the Clinical Spectrum

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza   +19 more
wiley   +1 more source

Cosine family with weak singularity

open access: yesUniversitatis Iagellonicae Acta Mathematica, 2000
Summary: The main goal of the paper is to present a construction of the cosine family with weak singularity and to present its application to evolution Cauchy problems of the following form: \[ {d^2u(t)\over dt^2}= B^2u(t)+ g(t),\;t\in\mathbb{R}, \] \[ u(0)=u_0,\;u'(0)=u_1,\;u_0,u_1\in X, \] where \(X\) is a Banach space and \(B:X\to X\) a closed ...
openaire   +2 more sources

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon   +11 more
wiley   +1 more source

Weak null singularities in general relativity

open access: yesJournal of the American Mathematical Society, 2017
We construct a class of spacetimes (without symmetry assumptions) satisfying the vacuum Einstein equations with singular boundaries on two null hypersurfaces intersecting in the future on a 2-sphere. The metric of these spacetimes extends continuously beyond the singularities while the Christoffel symbols fail to be square integrable in a neighborhood ...
openaire   +2 more sources

sylabs/singularity: Singularity 3.0.2 release candidate 1

open access: yes, 2018
<p>Seasons greetings Singularity community!</p> <p>The Singularity elves have been hard at work and the holidays are coming a little early this year!</p> <p>:gift:</p> <p>This is a release candidate for ...
David Godlove   +29 more
core   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou   +16 more
wiley   +1 more source

qbicsoftware/qbic-singularity-snpeff: First major release

open access: yes, 2017
<p>First major release of the Singularity container with SnpEff</p ...
Sven F., Alexander Peltzer
core   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay   +13 more
wiley   +1 more source

Singularity of a class of degenerate parabolic systems with tme-dependent coefficients

open access: yes四川大学学报. 自然科学版, 2021
In this paper, we study the singularity and global regularity of a class of degenerate parabolic systems with time-dependent coefficients and Neumann boundary condition.
HU Li, FAN Ming-Shu
doaj  

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

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