Results 171 to 180 of about 634,419 (341)

Global solutions to a one-dimensional nonlinear wave equation derivable from a variational principle

open access: yesElectronic Journal of Differential Equations, 2017
This article focuses on a one-dimensional nonlinear wave equation which is the Euler-Lagrange equation of a variational principle whose Lagrangian density involves linear terms and zero term as well as quadratic terms in derivatives of the field.
Yanbo Hu, Guodong Wang
doaj  

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao   +34 more
wiley   +1 more source

Existence of solutions for a variational unilateral system

open access: yesElectronic Journal of Differential Equations, 2002
In this work the authors study the existence of weak solutions of the nonlinear unilateral mixed problem associated to the inequalities $$ displaylines{ u_{tt}-M(| abla u| ^{2})Delta u+heta geq f, cr heta_t-Delta heta +u_tgeq g ,} $$ where $f$, $g$, $M ...
Marcondes R. Clark, Osmundo A. Lima
doaj  

Heterozygous variants in AP4S1 are not associated with a neurological phenotype

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Abstract Biallelic loss‐of‐function variants in AP4S1 cause childhood‐onset hereditary spastic paraplegia. A recent report suggested that heterozygous AP4S1 variants lead to a syndrome of lower limb spasticity and dysregulation of sphincter function. We critically evaluate this claim against clinical observations in 28 heterozygous carriers of the same
Vicente Quiroz   +9 more
wiley   +1 more source

Existence of global weak solutions for a p-Laplacian inequality with strong dissipation in noncylindrical domains

open access: yesElectronic Journal of Differential Equations, 2022
Jorge Ferreira   +4 more
doaj  

Handling rescue therapy in myasthenia gravis clinical trials: why it matters and why you should care

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Abstract Myasthenia gravis (MG) clinical trials typically allow rescue therapy during follow‐up in the event of marked worsening of MG symptoms. Failure to appropriately address rescue therapy in defining treatment effects and planning statistical analyses may yield biased estimates, increase false positive rates, or decrease statistical power – all of
Justin M. Leach   +3 more
wiley   +1 more source

The influence of damping and source terms on solutions of nonlinear wave equations

open access: yesBoletim da Sociedade Paranaense de Matemática, 2007
We discuss in this paper some recent development in the study of nonlinear wave equations. In particular, we focus on those results that deal with wave equations that feature two competing forces.One force is a damping term and the other is a strong ...
Mohammad A. Rammaha
doaj  

If it does not help, it might hurt: Pharmacodynamics of a second IVIg course in Guillain–Barré syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives Intravenous immunoglobulin (IVIg) is an effective treatment for Guillain–Barré syndrome (GBS), but recovery varies between patients. This study aims to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of a single and a second IVIg dose (SID) in patients with GBS.
Sander J. van Tilburg   +7 more
wiley   +1 more source

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