Results 31 to 40 of about 1,612,054 (235)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Towards effective practice in offender supervision [PDF]

, 2009
This paper has been prepared principally for the Performance Improvement Strategy Group - a group convened by the Community Justice Division of the Scottish Government to advise and assist in the development of criminal justice social work services in ...
McNeill, Fergus, Scottish Centre for Crime and Justice Research (Funder)   +1 more
core   +3 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Applying weak supervision to classify scarce labeled technical documents

, 2021
The digitalization in the construction industry, the number of project relevant documents. It becomes a challenge to organize documents in a searchable manner by classification.
Hoffmann, André, Shi, Meiling, Rüppel, Uwe, A. Hoffmann, M. Shi, U. Rüppel   +5 more
core   +1 more source

Zero‐shot insect detection via weak language supervision

Plant Phenome Journal
Cheap and ubiquitous sensing has made collecting large agricultural datasets relatively straightforward. These large datasets (for instance, citizen science data curation platforms like iNaturalist) can pave the way for developing powerful artificial ...
Benjamin Feuer, Ameya Joshi, Minsu Cho, Shivani Chiranjeevi, Zi Kang Deng, Aditya Balu, Asheesh K. Singh, Soumik Sarkar, Nirav Merchant, Arti Singh, Baskar Ganapathysubramanian, Chinmay Hegde   +11 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Improving the performance of weak supervision searches using data augmentation

Journal of High Energy Physics
Weak supervision combines the advantages of training on real data with the ability to exploit signal properties. However, training a neural network using weak supervision often requires an excessive amount of signal data, which severely limits its ...
Zong-En Chen, Cheng-Wei Chiang, Feng-Yang Hsieh   +2 more
doaj   +1 more source

Legal Politics of Village Fund Supervision in Preventing Potential Corruption in Indonesia

Sociological Jurisprudence Journal
Corruption cases related to the misuse of village funds in Indonesia remain a particular problem for the implementation of the village administration system.
Dewi Ambarwati, Muchammad Ja’far Shodiq   +1 more
doaj   +1 more source