Results 111 to 120 of about 3,721,262 (281)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Weak values and weak coupling maximizing the output of weak measurements [PDF]
Annals of Physics, 2014 In a weak measurement, the average output $\langle o\rangle$ of a probe that measures an observable $\hat{A}$ of a quantum system undergoing both a preparation in a state $ρ_i$ and a postselection in a state $E_\mathrm{f}$ is, to a good approximation, a function of the weak value $A_w=\mathrm{Tr} [E_f \hat{A} ρ_i]/\mathrm{Tr}[E_fρ_i]$, a complex number.
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Quantum logic and weak values [PDF]
, 2013 In this study, we study weak values from a quantum-logical viewpoint. In addition, we examine the validity of the counterfactual statements of Hardy's paradox, which are based on weak values, and we show that these statements have not been validated.
Mochizuki, Riuji
core
An Introduction to Weak Values
Latin America Optics and Photonics Conference, 2014 I will give a brief background to weak values, discuss their implications and review some of the recent experiments employing weak value techniques including: weak value amplification, wave function measurement and technical noise suppression. Article not available.
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source