Results 41 to 50 of about 51,002 (217)

Liftable derivations for generically separably algebraic morphisms of schemes

open access: yes, 2006
We consider dominant, generically algebraic, and tamely ramified (if the characteristic is positive) morphisms $\pi: X/S \to Y/S$, where Y,S are Noetherian and integral and X is a Krull scheme (e.g.
Källström, Rolf
core   +4 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

On Weakly von Neumann regular rings

open access: yes, 2009
In this paper, we define and study a particular case of von Neumann regular notion called a weak von Neumann regular ring. It shown that the polynomial ring $R[x]$ is weak von Neumann regular if and only if $R$ has exactly two idempotent elements. We provide necessary and sufficient conditions for $ R=A\propto E $ to be a weak von Neumann ring.
Kabbour, Mohammed, Mahdou, Najib
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Some Results on W-regular Rings

open access: yesNTU Journal of Pure Sciences
Von Neumann regular rings, introduced in 1936, form a cornerstone of abstract algebra and were later extended to weakly regular rings. This work considers another extension, the W-regular rings defined by Wei [6], and explores their properties and ...
Hazim Tallat Hazim
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

A construction of weakly and non-weakly regular bent functions over the ring of integers modulo $$p^m$$ p m

open access: yesApplicable Algebra in Engineering, Communication and Computing, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Celik, Dilek, Ozbudak, Ferruh
openaire   +2 more sources

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