Results 91 to 100 of about 1,392,301 (300)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Protocol for diaphragm pacing in patients with respiratory muscle weakness due to motor neurone disease (DiPALS): a randomised controlled trial

BMC Neurology, 2012
Background Motor neurone disease (MND) is a devastating illness which leads to muscle weakness and death, usually within 2-3 years of symptom onset.
McDermott Christopher J, Maguire Chin, Cooper Cindy L, Ackroyd Roger, Baird Wendy O, Baudouin Simon, Bentley Andrew, Bianchi Stephen, Bourke Stephen, Bradburn Mike J, Dixon Simon, Ealing John, Galloway Simon, Karat Dayalan, Maynard Nick, Morrison Karen, Mustfa Naveed, Stradling John, Talbot Kevin, Williams Tim, Shaw Pamela J   +20 more
doaj   +1 more source

[Review of the book \u3ci\u3eRetirement Income Opportunities in an Aging America: Income Levels and Adequacy\u3c/i\u3e] [PDF]

, 1983
[Excerpt] The slant of this volume will not appeal to everyone. Consider the following: During the last twenty years, the elderly\u27s financial status has improved substantially. Today those who are over age 65 receive income from more sources and have
Fields, Gary S
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Effect of Sensor Monitored Upright Sitting on Core Muscle Thickness, Contractibility and Spinal Posture among Asymptomatic University Students: A Study Protocol for RCT [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Prolonged sitting in classrooms predisposes students to poor posture, muscle imbalance, and low back pain. Tonic activation of the core muscles that stabilise the spine increases when seated upright, and this may have positive ...
Varsha Huddar, Sanjiv Kumar, Ashwin Patil   +2 more
doaj   +1 more source

Iranian Muslim Reformists and Contemporary Ethics; Revival of “Utilitarianism" [PDF]

, 2017
This paper raises a moral issue for contemporary post-revolutionary Muslim intellectuals in Iran. According to traditional Islamic teachings, ethics enables people to transcend from this mundane world and offers guidance on ways to improve virtues.
Dabbagh, Hossein
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Muscular dystrophies: key elements for everyday diagnosis and management

Cardiogenetics, 2013
Muscular dystrophies are a heterogeneous group of inherited disorders that share similar clinical features and dystrophic changes on muscle biopsy, associated with progressive weakness. Weakness may be noted at birth or develop in late adult life.
Alberto Palladino, Gerardo Nigro, Luisa Politano   +2 more
doaj   +1 more source

Intention and Weakness of Will [PDF]

The Journal of Philosophy, 1999
L'A. definit la faiblesse de la volonte non pas en termes de choix malheureux entre une bonne et une mauvaise action, mais en termes d'incapacite a suivre l'intention qu'on s'est prealablement fixee, a cause d'une tendance excessive a reconsiderer ses intentions. Se referant a l'oeuvre de M. Bratman et G.
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source