Results 91 to 100 of about 400,831 (317)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The strengths and weaknesses of practical reason [PDF]
, 2004 Voice in the debate: The practical philosophy of Immanuel Kant - its strength and ...
Galewicz, Włodzimierz
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Covert Action: Strengths and Weaknesses [PDF]
, 2010 This article discusses the strengths and weaknesses of covert action as a tool for American foreign policy. It examines the strengths and weaknesses of covert action against the yardstick of success and against the yardstick of policy coherence.
William J. Daugherty
core +1 more source
Introduction and criticism of the book Homelessness and Social Policy [PDF]
مسائل اجتماعی ایران, 2023 The book Homelessness and Social Policy is written by Rogers Burroughs, Nicholas Place and Deborah Quilgars; which was translated by Mohammad Khani; And it has been published in 2017 by the Scientific and Cultural Publishing House at the request of the ...
Javad Maddahi +2 more
doaj
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Logic Journal of the IGPL, 2020 Abstract It is well-known that adding to a lattice the usual relative meet complement is not conservative, in the sense that distributivity is implied. In this paper we consider a weak relative meet complement that does not have the mentioned effect. We mostly study the mentioned operation from an algebraic point of view.
Castiglioni, José Luis +1 more
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source