Results 91 to 100 of about 214,828 (269)

Status and weaknesses of epidemiological investigation and emergency response in Guizhou Province, China

Journal of Infection in Developing Countries
Introduction: Epidemiological investigation and emergency response are crucial during public health emergencies. This work investigated the status and weaknesses of the Center for Disease Control and Prevention (CDC) system in Guizhou Province, China ...
Yun Gou, Yan Huang, Chun Yu, Can Hu, Zhongfa Tao, Jiao Huang, Bing Deng, Mingyu Lei   +7 more
doaj   +1 more source

A study on the strengths، weaknesses، opportunities and threats of Iranian smart schools [PDF]

فصلنامه نوآوری‌های آموزشی, 2010
The main purpose of this study was to examine the strengths، weaknesses، opportunities and threats (SWOT) that Iranian smart schools were confronted with. Another purpose was conducting a comparison between SWOT of governmental and private smart schools.
BiBi Eshrat Zamani, Bita Ghassab Pour, Jalal Jabal Ameli   +2 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Designing and Implementing the acaSTEMy Project – Trans-national Science, Technology, Engineering, and Mathematics Teacher Education Focusing on Transversal Competences and Sustainable Education

Science Education International
This article addresses the internationally recognized need to strengthen the competences, professional capacity, and motivation of science, technology, engineering, and mathematics (STEM) educators working in schools, higher education institutions, and ...
Miia Rannikmäe, Regina Soobard
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The Investigation and Analysis of the Strengths, Weaknesses, Opportunities, and Threats of Wearable Electronic Technologies: A Systematic Review

مجله انفورماتیک سلامت و زیست پزشکی, 2020
Introduction: Wearable electronic devices, which are based on Internet of Things (IoT) and big data computing, are able to continuously collect and process the physiological and environmental data and exchange them with other tools, users, and internet ...
Zaiddodine Pashandi, Hanif Kazerooni, Hossein Hassanpoor   +2 more
doaj  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source