Results 51 to 60 of about 214,828 (269)
If the weak were strong and the strong were weak [PDF]
SciPost Physics, 2019 We explore the phase structure of the Standard Model as the relative strengths of the SU(2) S U ( 2
Tong, David, Lohitsiri, Nakarin
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Weaknesses of Weak Preemptionism
The Philosophical Quarterly, 2020 Abstract According to preemptionism, a layperson should treat the fact that an epistemic authority believes p as a reason to believe p that replaces her other reasons relevant to believing p and is not simply added to them. Many authors have found the unqualified version of preemptionism, as defended by Linda Zagzebski, too strong.
openaire +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
ACTIVITIES TO ANTICIPATE THE WEAKNESSES OF STUDENTS’ READING MATERIALS FROM INTERNET
Lire Journal, 2020 The shift of the way of reading from printed material into non-printed material (reading from the computer, tablet, and smartphone) happened in the past few years ago.
Maria Eka Mulatsih
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
What happens when coachees explore their strengths? [PDF]
International Journal of Evidence Based Coaching and Mentoring, 2011 Recent research largely focuses on measuring the outcomes of strengths-based coaching but fails to consider coachees’ individual experience of the process.
Teresa Clifford
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CONSIDERATIONS ON THE MODELS OF ECONOMIC DEVELOPMENT [PDF]
Annals of the University of Petrosani: Economics, 2022 This paper displays in detail the three large categories of successful economic development models worldwide: the Anglo-American model, the European model and the Asian model.
ROLAND-EDUARD KACSO-DOBOLY
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