Results 31 to 40 of about 50,538 (260)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Wearable Cardiorespiratory Sensors for Aerospace Applications
Sensors, 2022 Emerging Air Traffic Management (ATM) and avionics human–machine system concepts require the real-time monitoring of the human operator to support novel task assessment and system adaptation features. To realise these advanced concepts, it is essential to resort to a suite of sensors recording neurophysiological data reliably and accurately.
Nichakorn Pongsakornsathien +4 more
openaire +4 more sources
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley +1 more source
Flexible Wearable Pressure Sensor Based on Collagen Fiber Material
Micromachines, 2022 Flexible wearable pressure sensors play a pivotal role in healthcare monitoring, disease prevention, and humanmachine interactions. However, their narrow sensing ranges, low detection sensitivities, slow responses, and complex preparation processes ...
Zhiqing Peng +8 more
doaj +1 more source
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Critical review of potential technologies for a wearable benzene sensor system
Sensors and Actuators ReportsWe evaluate different methods to detect benzene at a parts-per-billion level regarding their potential to be used in a wearable sensor. Benzene is a carcinogenic molecule, regarded as a major health threat by the World Health Organization.
Tim Dunker +3 more
doaj +1 more source
Recent Progress in Wireless Sensors for Wearable Electronics
Sensors, 2019 The development of wearable electronics has emphasized user-comfort, convenience, security, and improved medical functionality. Several previous research studies transformed various types of sensors into a wearable form to more closely monitor body ...
Young-Geun Park +2 more
doaj +1 more source
A Wearable Patch Sensor for Simultaneous Detection of Dopamine and Glucose in Sweat
Analytica, 2023 Achieving quantification of biomarkers in body fluids is crucial to the indication of the state of a person’s body and health. Wearable sensors could offer a convenient, fast and painless sensing strategy.
Yue Sun +8 more
doaj +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source