Results 81 to 90 of about 2,986,600 (358)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Personality, geography, and socio-demography: A Danish survey among adult men

International Journal of Personality Psychology
Personality may vary with geography and with socio-demographical determinants. Research is, however, limited to a few countries and often involves only selected groups of the population, like students.
Søren Birkeland, Anders Haakonsson, Sören Möller   +2 more
doaj   +1 more source

Long-Term Side Effects of Adjuvant Therapy in Primary Breast Cancer Patients: Results of a Web-Based Survey

Breast Care, 2019
Background: Chronic treatment sequelae may substantially reduce the long-term quality of life in breast cancer survivors. Methods: We report a comprehensive Web-based survey on the presence of long-term side effects of adjuvant anti-breast cancer therapy
R. Haidinger, I. Bauerfeind
semanticscholar   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Ocular adverse events associated with eye makeup: a cosmetovigilance-based cross-sectional study of prevalence and predictors among Jordanian women

Frontiers in Public Health
This study aimed to investigate eye makeup adverse reactions (ARs), habits and practices among Jordanian females. The research also sought to identify factors contributing to the risk of ARs to promote safer cosmetic practices and protect public health ...
Mohammad Abusamak, Sura Al Zoubi, Amal F. Alomari, Sara M. Issa, Ayman A. Abdul Aziz, Asma Musleh, Hala Alrfooh, Yazun Bashir Jarrar, Rasmieh Al-Amer, Roa'a Hamzeh, Lena Al-Kuran, Talal M. Abusamak   +11 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Web-based surveys as an alternative to traditional mail methods [PDF]

Journal of Environmental Management, 2009
Environmental economists have long used surveys to gather information about people's preferences. A recent innovation in survey methodology has been the advent of web-based surveys. While the Internet appears to offer a promising alternative to conventional survey administration modes, concerns exist over potential sampling biases associated with web ...
Fleming, C.M., Bowden, M.
openaire   +5 more sources

Folksonomies, the semantic web, and movie recommendation [PDF]

, 2007
While the Semantic Web has evolved to support the meaningful exchange ofheterogeneous data through shared and controlled conceptualisations, Web 2.0 has demonstrated that large-scale community tagging sites can enrich the semantic web with readily ...
C. CATTUTO, M. SZOMSZOR, V. D. P. SERVEDIO, A. ALANI, Szomszor, Martin, Alani, Harith, O'Hara, Kieron, O’Hara, Kieron, A. BALDASSARRI, Servedio, Vito D.P., Cattuto, Ciro, Baldassarri, Andrea, Loreto, Vittorio, K. O'HARA   +13 more
core  

The relationship between web enjoyment and student perceptions and learning using a web-based tutorial

, 2005
Web enjoyment has been regarded as a component of system experience. However, there has been little targeted research considering the role of web enjoyment alone in student learning using web-based systems. To address this gap, this study aims to examine
Macredie, RD, Chen, SY, Mitchell, TJF
core   +1 more source