Results 31 to 40 of about 810,994 (255)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Web site como ambiente de comunicação: uma análise da usabili- dade dos web sites dos Convention & Visitors Bureau do Estado de Santa Catarina [PDF]

PASOS Revista de Turismo y Patrimonio Cultural, 2011
Aware that quality information is essential for any organization, which means that there must be information systems easier to use. For this need for quality information and good usability makes the User Interface fundamental part of information systems.
Adriana Gomes de Moraes
doaj   +3 more sources

Request for confirmation sequences in Castilian Spanish

Open Linguistics
This article analyzes request for confirmation (RfC) sequences in spoken Castilian Spanish. RfCs are conversational turns that present a proposition for which the speaker claims some knowledge but at the same time asks for an informed co-participant’s ...
Ehmer Oliver
doaj   +1 more source

Problems of involvement of disabled persons in e. government / Dalyvavimo elektroninėje valdžioje problemos

Technological and Economic Development of Economy, 2008
The European Union Sustainable Development Strategy stated that sustainable development was a long‐term European Union's strategy safeguarding clean and healthy environment and better quality of life for the present and future generations.
Eglė Kažemikaitienė, Tatjana Bilevičienė   +1 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Web Site Engineeering : Ein Komponentenmodell [PDF]

, 1998
Die nähere Betrachtung des Konstrukts \u27Web Site\u27 (Arbeitspapier WI, Nr. 11/1998) unterbaut das Ergebnis der Analyse aus Sicht der Neuen Institutionenökonomik (Arbeitspapier WI, Nr.
Schwickert, Axel C.
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Dimensions of web site credibility and their relation to active trust and behavioural impact [PDF]

, 2009
This paper discusses two trends that threaten to undermine the effectiveness of online social marketing interventions: growing mistrust and competition.
Cugelman, Brian, Dawes, Philip L., Thelwall, Mike   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source