Results 41 to 50 of about 2,562,713 (313)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Web Content Accessibility Guidelines 1.0

, 2008
Aquesta és una traducció catalana autoritzada d'un document del W3C. La publicació d'aquesta traducció ha seguit els passos descrits en la política de traduccions autoritzades W3C.
Térmens i Graells, Miquel, Ribera, Mireia, Sulé, Andreu   +2 more
core   +1 more source

Directrius per a l'accessibilitat al contingut de pàgines web, versió 1.0 : resum

BiD: Textos Universitaris de Biblioteconomia i Documentació, 1999
Les Directrius per a l'accessibilitat al contingut de pàgines web tenen l'objectiu de promoure l'accessibilitat del contingut de la web per a persones amb discapacitats, però també d'ajudar a trobar la informació dins el web i facilitar-ne l'ú a tot ...
World Wide Web Consortium
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Cold-formed steel sections with web openings subjected to web crippling under two-flange loading conditions — Part II : Parametric study and proposed design equations [PDF]

, 2012
A parametric study of cold-formed steel sections with web openings subjected to web crippling was undertaken using finite element analysis, to investigate the effects of web holes and cross-section sizes on the web crippling strengths of channel sections
Uzzaman, Asraf, Young, Ben, Rhodes, James, Rhodes, Jim, Young, B, Lim, JBP, Nash, D, Uzzaman, A, Nash, David, Lim, James, Lim, James B. P., Rhodes, J   +11 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Smartphone e GNSS per l'utilizzo professionale

GEOmedia, 2017
Smartphones and tablets are nowadays more and more complex, and almost all of them include GNSS modules and other sensors for user localization. After the start of Galileo positioning services, the final positioning quality from mobile devices is ...
Mattia DeAgostino, Luca Guida, davide portinaro, Luca Raso, Massimo Galluzzi   +4 more
doaj   +2 more sources

Key Management Systems at the Cloud Scale

Cryptography, 2019
This paper describes a cloud-scale encryption system. It discusses the constraints that shaped the design of Amazon Web Services’ Key Management Service, and in particular, the challenges that arise from using a standard mode of operation such as ...
Matthew Campagna, Shay Gueron
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Shared Protentions in Multi-Agent Active Inference

Entropy
In this paper, we unite concepts from Husserlian phenomenology, the active inference framework in theoretical biology, and category theory in mathematics to develop a comprehensive framework for understanding social action premised on shared goals.
Mahault Albarracin, Riddhi J. Pitliya, Toby St. Clere Smithe, Daniel Ari Friedman, Karl Friston, Maxwell J. D. Ramstead   +5 more
doaj   +1 more source