Results 61 to 70 of about 532,335 (350)
FEBS Open Bio, EarlyView.Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley +1 more source
Most autophagic cell death studies lack evidence of causality
FEBS Open Bio, EarlyView.Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley +1 more source
FEBS Open Bio, EarlyView.Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura +7 more
wiley +1 more source
Understanding and supporting web developers: : design and evaluation of a web accessibility information resource (WebAIR) [PDF]
, 2016 This paper describes the design and evaluation of a Web Accessibility Information Resource (WebAIR) for supporting web developers to create and evaluate accessible websites.
Petrie, Helen +2 more
core
Designing Universally Accessible Networking Services for a Mobile Personal Assistant [PDF]
, 2009 At present, a tendency towards smaller computer sizes and at the same time increasingly inaccessible web content can be noted. Despite the worldwide recognized importance of Web accessibility, the lack of accessibility of web services has an increasingly
B.N. Schilit +4 more
core +1 more source
Usage of Artificial Intelligence Tools to Improve Digital Web Accessibility
Digital Presentation and Preservation of Cultural and Scientific HeritageAccessibility of websites considers challenges related to creation of web pages adapted to user with different types of impairments. The goal of web accessibility is to remove barriers that may prevent people with disabilities from accessing or ...
Todor Todorov
doaj +1 more source
Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations
FEBS Open Bio, EarlyView.Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro +8 more
wiley +1 more source
Techniques for the Publication of Accessible Multimedia Content on the Web
IEEE Access, 2020 Multimedia has become one of the most important sources of information and communication on the web. However, despite recent technological progress, people with disabilities and the elderly face difficulties accessing multimedia on the web. In some cases,
Tania Acosta +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Learner-centred Accessibility for Interoperable Web-based Educational Systems [PDF]
, 2005 This paper describes the need for an information model and specifications that support a new strategy for delivering accessible computer-based resources to learners based on their specific needs and preferences in the circumstances in which they are ...
Andy Heath +5 more
core +1 more source