Results 71 to 80 of about 559,345 (343)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Designing Universally Accessible Networking Services for a Mobile Personal Assistant [PDF]

, 2009
At present, a tendency towards smaller computer sizes and at the same time increasingly inaccessible web content can be noted. Despite the worldwide recognized importance of Web accessibility, the lack of accessibility of web services has an increasingly
B.N. Schilit, F. George, M. Jones, O. Buyukkokten, X. Xiao   +4 more
core   +1 more source

Subcontractació de webs accessibles : què hem de vigilar?

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2010
S'explica com es gestiona la subcontractació d'un web accessible, especialment des d'un organisme públic. Així, s'estableixen criteris que cal incloure en el plec de condicions que afecten el proveïdor, el procés de disseny del web i l'eina que s'usarà ...
Ribera, Mireia
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Usage of Artificial Intelligence Tools to Improve Digital Web Accessibility

Digital Presentation and Preservation of Cultural and Scientific Heritage
Accessibility of websites considers challenges related to creation of web pages adapted to user with different types of impairments. The goal of web accessibility is to remove barriers that may prevent people with disabilities from accessing or ...
Todor Todorov
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Learner-centred Accessibility for Interoperable Web-based Educational Systems [PDF]

, 2005
This paper describes the need for an information model and specifications that support a new strategy for delivering accessible computer-based resources to learners based on their specific needs and preferences in the circumstances in which they are ...
Andy Heath, Jutta Treviranus, La Trobe, Liddy Nevile, Madeleine Rothberg, Martyn Cooper   +5 more
core   +1 more source

On the Change in Archivability of Websites Over Time [PDF]

, 2013
As web technologies evolve, web archivists work to keep up so that our digital history is preserved. Recent advances in web technologies have introduced client-side executed scripts that load data without a referential identifier or that require user ...
B. Parmanto, E. Crook, F. McCown, F. McCown, M. Prellwitz, P. Likarish, S.G. Ainsworth, W. Chisholm   +7 more
core   +4 more sources

Content Accessibility Evaluation of Government Website using WCAG (Web Content Accessibility Guidelines)

Annals of computer science and information systems, 2017
A well designed and highly accessible websites are very important for organizations to communicate with different categories of the users in this IT world.
Swikruti Dongaonkar, Ramkrishna Vadali, Chandrakant Dhutadmal   +2 more
doaj   +1 more source

Web Accessibility Challenges [PDF]

International Journal of Advanced Computer Science and Applications, 2016
A pesar de la importancia de la accesibilidad web en los últimos años, los sitios web siguen siendo parcial o completamente inaccesibles para ciertos sectores de la población. Esto se debe a varias razones, incluida la poca o ninguna experiencia de los desarrolladores web en accesibilidad y la falta de información precisa sobre las mejores formas de ...
Hayfa Y. Abuaddous, Mohd Zalisham, Nurlida Basir   +2 more
openaire   +1 more source