Results 121 to 130 of about 228,143 (180)
Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 157-166, January 2023., 2023 For radical surgery after induction gemcitabine along with nab‐paclitaxel and subsequent chemoradiotherapy for unresectable locally advanced pancreatic ductal adenocarcinoma, CA19‐9 normalization and maintenance of good nutritional status during treatment until surgery were important for prolonged prognosis.
Takamichi Igarashi +9 more
wiley +1 more source
Advanced Science, EarlyView.This study develops RLS‐2, a high‐affinity aptamer that specifically targets injured podocytes, making it a promising candidate for targeted drug delivery. In vitro, RLS‐2 shows stability, specificity, efficient siRNA delivery via AsiCs, and uptake by podocytes.
Chao Zhou +9 more
wiley +1 more source
Low‐Irradiance Antimicrobial Blue Light‐Bathing Therapy for Wound Infection Control
Advanced Science, EarlyView.Antimicrobial blue light has been shown as an appealing non‐pharmacological antimicrobial alternative. However, its clinical applications have been hindered by high irradiance‐associated photothermal risks. In this work, a low‐irradiance blue light‐bathing concept and a wearable photonic wound patch are established to address this challenge in terms of
Jie Hui +12 more
wiley +1 more source
Drop breakage in a single‐pass through vortex‐based cavitation device: Experiments and modeling
AIChE Journal, Volume 69, Issue 1, January 2023., 2023 Abstract Liquid–liquid emulsions are used in many sectors such as personal care, home care, and food products. There is an increasing need for developing compact and modular devices for producing emulsions with desired droplet size distribution (DSD). In this work, we have experimentally and computationally investigated an application of vortex‐based ...
Abhijeet H. Thaker, Vivek V. Ranade
wiley +1 more source
Electrostatically Reinforced Double Network Granular Hydrogels
Advanced Science, EarlyView.Electrostatically reinforced double network granular hydrogels (DNGHs) with cartilage‐like fracture energy are introduced. An empirical model predicts the composition‐dependent fracture energy based on dissipation zone size, contact area, and inter‐particle adhesion energy. Thanks to their granular structure and the inter‐particle attraction, the DNGHs
Tianyu Yuan +3 more
wiley +1 more source
Flowsheet generation through hierarchical reinforcement learning and graph neural networks
AIChE Journal, Volume 69, Issue 1, January 2023., 2023 Abstract Process synthesis experiences a disruptive transformation accelerated by artificial intelligence. We propose a reinforcement learning algorithm for chemical process design based on a state‐of‐the‐art actor‐critic logic. Our proposed algorithm represents chemical processes as graphs and uses graph convolutional neural networks to learn from ...
Laura Stops +3 more
wiley +1 more source
Bioinspired Strong and Tough Layered Bulk Composites via Mycelial Interface Anchoring Strategy
Advanced Science, EarlyView.An interface anchoring strategy, which fixes the interface between the soft and hard phases to immobilize 2D materials, by leveraging the growth of biological living mycelium is proposed. This approach results in the formation of a lightweight and strong composite material (the LBCs) with a layered structure composed of soft and hard phases.
Hao Wang +6 more
wiley +1 more source
An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis
Advanced Science, EarlyView.The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari +20 more
wiley +1 more source
DAPK3 is Essential for DBP‐Induced Autophagy of Mouse Leydig Cells
Advanced Science, EarlyView.This study has confirmed that death‐associated protein kinase 3 (DAPK3) is essential for dibutyl phthalate (DBP)‐induced autophagy of mouse Leydig cells, and is regulated by both transcription factor specific protein 2 (Sp2) and parkin RBR E3 ubiquitin‐protein ligase (PRKN), and melatonin can alleviate DBP‐induced autophagy of the cells.
Si Yang +4 more
wiley +1 more source