Results 41 to 50 of about 197,873 (270)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

DEVELOPING AN ONLINE CORPUS OF FORMOSAN LANGUAGES [PDF]

Taiwan Journal of Linguistics, 2008
Information technologies have now matured to the point of enabling researchers to create a repository of language resources, especially for those languages facing the crisis of endangerment. The development of an online platform of corpora, made possible
Li-May Sung, Lily I-wen Su, Fuhui Hsieh, Zhemin Lin   +3 more
doaj  

Can user recommendations be useful for improving MOOCs accessibility? A project for inclusive design and profitable feedback [PDF]

, 2016
At present there are no applications which include accessibility revisions for Massive Open Online Courses (MOOCs), neither in the context of MOOCs provider institutions nor from the point of view of any Open Educational Resource (OER) initiative.
Iniesto, Francisco, Rodrigo, Covadonga
core  

Information Technology and the Workplace: Implications for Persons with Disabilities [PDF]

, 2005
The Internet improves access to employment and community for many people. However, there is growing concern that many Web sites are inaccessible to people with certain disabilities.
Bruyere, Susanne M, Erickson, William, VanLooy, Sara   +2 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Digital transformation of population administration: Enhancing data accessibility in local communities

Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang
This community service initiative addresses the need for an efficient population administration system in RT3/RW3, Rejowinangun Utara Village, Magelang, where several key issues hinder effective data management.
Ozzi Suria, Putri Taqwa Prasetyaningrum, Irfan Pratama   +2 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Guidelines for evaluating web accessibility, level A

Journal of Computer Science and Technology, 2013
The Web Accessibility Initiative (WAI) defines the guidelines to facilitate access for people with disabilities to ICT. This article presents a proposal to promote the unification and improvement of the works of two authors, combining the procedures and ...
Juan J. Acevedo, Laura Gómez Solis, Sonia Itatí Mariño, María Viviana Godoy Guglielmone   +3 more
doaj