Results 41 to 50 of about 142,745 (298)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Considerations Regarding Designing and Administrating SOA Solutions [PDF]

Database Systems Journal, 2011
Solutions like SOA, Cloud, SaaS, Iaas or PaaS are not only buzzwords, they became a business reality because they are relative cheap and easy to use. SOA and Cloud are tightly linked because most cloud solutions are being defined using SOA making them ...
Vlad DIACONITA
doaj  

Towards a Process Calculus for Rest: Current State of the Art

Foundations of Computing and Decision Sciences, 2015
SOA is a popular paradigm for building distributed systems that has gained a great recognition over past years. There are two main approaches to implementing SOA: SOAP-based and RESTful Web services.
Dwornikowski Dariusz, Stroiński Andrzej, Brzeziński Jerzy   +2 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A Collaborative System Software Solution for Modeling Business Flows Based on Automated Semantic Web Service Composition [PDF]

Informatică economică, 2009
Nowadays, business interoperability is one of the key factors for assuring competitive advantage for the participant business partners. In order to implement business cooperation, scalable, distributed and portable collaborative systems have to be ...
Ion SMEUREANU, Andreea DIOSTEANU
doaj  

Development of ISIRS Web Application Using Object Behavioral Modeling

Journal of Kufa for Mathematics and Computer, 2010
The growth of the Internet and the World Wide Web (WWW) has resulted in a large number of Web Systems and Web Applications. Today many people are relying on Web applications like Internet banking, entertainment and E-commerce applications.
Haider M. Abdul-Nabi
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Modeling international crisis synchronization in the world trade web

Networks and Heterogeneous Media, 2012
Trade is a fundamental pillar of economy and a form of social organization. Its empirical characterization at the worldwide scale is represented by the World Trade Web (WTW), the network built upon the trade relationships between the different countries.
Pau Erola, Albert Díaz-Guilera, Sergio Gómez, Alex Arenas   +3 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Data-Parallel Web Crawling Models [PDF]

, 2004
The need to quickly locate, gather, and store the vast amount of material in the Web necessitates parallel computing. In this paper, we propose two models, based on multi-constraint graph-partitioning, for efficient data-parallel Web crawling. The models aim to balance the amount of data downloaded and stored by each processor as well as balancing the ...
Cambazoglu, B.B., Turk, A., Aykanat, C.
openaire   +2 more sources