Results 41 to 50 of about 853,365 (284)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Artificial intelligence for radiographic detection of urinary stones in resource-constrained settings

Discover Artificial Intelligence
Urolithiasis is a common cause of emergency department visits, and early detection of urinary tract stones is critical to avoid complications, especially in healthcare systems with limited access to advanced imaging modalities.
Wesam Khazma, Ammer Alabed, Shaghaf Alhallak, Mohamad Bassam Kurdy   +3 more
doaj   +1 more source

WoS, WoK, CC, WoSCC…?!? [PDF]

Kemija u Industriji, 2014
This paper considers the changes related to the new Thomson Reuters Web of Science platform and databases that are available through it. Autor also clarified the potential confusion about the names of individual databases / citation indexes and their ...
Macan, B.
doaj  

How Reliable Are Impact Factors for Ranking Water Resources Journals? An Analysis of the 70,878 Citation Records of the 2002 and 2021 Top 10 Journals for the Last Two Decades

Water Resources Research, 2023
Despite regularly being criticized, the Impact Factor (IF) remains a widely used journal analysis metric. In the Water Resources category of the Web of Science, a thorough investigation of the reliability of this metric is lacking.
Valentijn R. N. Pauwels
doaj   +1 more source

What is critical for human-centered AI at work? – Toward an interdisciplinary theory

Frontiers in Artificial Intelligence, 2023
Human-centered artificial intelligence (HCAI) has gained momentum in the scientific discourse but still lacks clarity. In particular, disciplinary differences regarding the scope of HCAI have become apparent and were criticized, calling for a systematic ...
Athanasios Mazarakis, Christian Bernhard-Skala, Martin Braun, Isabella Peters   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Automated mitosis detection in stained histopathological images using Faster R-CNN and stain techniques

Journal of Integrative Bioinformatics
Accurate mitosis detection is essential for cancer diagnosis and treatment. Traditional manual counting by pathologists is time-consuming and may cause errors.
García-Salmerón Jesús, García José Manuel, Bernabé Gregorio, González-Férez Pilar   +3 more
doaj   +1 more source

ChatGPT: A meta-analysis after 2.5 months

Machine Learning with Applications
ChatGPT, a chatbot developed by OpenAI, has gained widespread popularity and media attention since its release in November 2022. However, little hard evidence is available regarding its perception in various sources.
Christoph Leiter, Ran Zhang, Yanran Chen, Jonas Belouadi, Daniil Larionov, Vivian Fresen, Steffen Eger   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Atomate It! End-user Context-Sensitive Automation using Heterogeneous Information Sources on the Web [PDF]

, 2010
The transition of personal information management (PIM) tools off the desktop to the Web presents an opportunity to augment these tools with capabilities provided by the wealth of real-time information readily available. In this paper, we describe a next-
André, Paul, Moore, Brennan, Van Kleek, Max G., schraefel, m. c., Karger, David R., m.c. schraefel, Van Kleek, Max, Max Van Kleek, David R. Karger, Paul André, schraefel, m.c., Karger, David, Brennan Moore   +12 more
core   +1 more source