Results 111 to 120 of about 1,764,054 (308)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

SMart Nanoparticle–Hydrogel Hybrid System for Synergistic Eradication of Infection and Promotion of Wound Healing

Advanced Science, EarlyView.
The integrated system, comprising bacterial‐targeted photothermal nanoparticles (Fe2O3‐CS@RBP) and multifunctional hydrogels (PAOC‐3@BA) modules, achieves rapid wound healing within one week. This work introduces a smart therapeutic platform that integrates bacterial targeting, self‐regulating photothermal therapy, tissue adhesion, and stimulus ...
Hongping Wan, Huirong Tan, Xinghong Zhao
wiley   +1 more source

Appraisals of Salient Visual Elements in Web Page Design

Advances in Human-Computer Interaction, 2016
Visual elements in user interfaces elicit emotions in users and are, therefore, essential to users interacting with different software. Although there is research on the relationship between emotional experience and visual user interface design, the ...
Johanna M. Silvennoinen, Jussi P. P. Jokinen   +1 more
doaj   +1 more source

Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat

Advanced Science, EarlyView.
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. ‌Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang, Huanyu Wang, Qianqian Kang, Ruping Pan, Rui He, Min Yang, Jiadai Liu, Xuemin Peng, Yuyu Xie, Hongyan Deng, Wenshe Wang, Zengzhe Zhu, Jing Ge, Yulian Liu, Ronghui Gao, Yaming Guo, Peng Yu, Limeng Pan, Danpei Li, Pema Maretich, Xiaoping Luo, Xuefeng Yu, Yong Chen   +22 more
wiley   +1 more source

An Approach to Page Ranking Based on Discourse Structures

Journal of Communications Software and Systems, 2016
World Wide Web (WWW) which is predominant source for Information Retrieval today (IR) is essentially a set of hyperlinked documents. A web page containing more number of related hyperlinks satisfy the user needs in a single page.
Subalalitha Chinnaudayar Navaneethakrishnan, Anita Ramalingam   +1 more
doaj  

RADA16 and SAAP148 Peptide‐Modified Collagen Self‐Assembled Hydrogels for Accelerated Healing of Infected Wounds

Advanced Science, EarlyView.
Collagen type I (Col I) is integrated with self‐assembling peptide RADA16 and loaded with anti‐bacterial peptide SAAP148 to develop a self‐assembled nano‐microstructure hydrogel (Col I‐RADA16‐SAAP148, CRS) without chemical cross‐linkers. CRS exhibits excellent mechanical properties, sustained SAAP148 release to inhibit bacterial infection, macrophage ...
Qian Liu, Jiawei Wu, Ho‐Pan Bei, Yufei Chen, Yifan Zhang, Xueliang Peng, Fulin Chen, Xin Zhao, Zhuoyue Chen   +8 more
wiley   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Aqueous Zinc‐Based Batteries: Active Materials, Device Design, and Future Perspectives

Advanced Energy Materials, EarlyView.
This review conducts a comprehensive analysis of aqueous zinc‐based batteries (AZBs) based on their intrinsic mechanisms, including redox reactions, ion intercalation reactions, alloying reactions, electrochemical double‐layer reactions, and mixed mechanisms, systematically discussing recent advancements in each type of AZBs.
Yan Ran, Fang Dong, Shuhui Sun, Yong Lei
wiley   +1 more source

Comparison of Web Page Rendering Methods Based on Next.js Framework Using Page Loading Time Test

Teknika
In the rapidly developing digital age, websites have become indispensable for interaction, information dissemination and transaction. To improve the performance of web applications, choosing the right rendering technology is critical.
Roy Hanafi, Abd Haq, Ninik Agustin
doaj   +1 more source

Strategic Advocacy for Higher Education Research: Insights From US Agricultural Experiment Station Funding

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Amidst dwindling state funding and the legislative withdrawal from public university research support, a heightened political process shapes the allocation of scarce tax dollars. This article explores how advocacy within the political process influences funding support for higher education from state legislatures.
Gregory M. Perry, Trey Malone, Jay T. Akridge   +2 more
wiley   +1 more source