Results 71 to 80 of about 1,770,021 (263)

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

open access: yesAdvanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin   +12 more
wiley   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

open access: yesAdvanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija   +22 more
wiley   +1 more source

Collaborative defending scheme against malicious Web pages based on social trust

open access: yesTongxin xuebao, 2012
To deal with the threat of malicious Web pages,a distributed defending scheme against malicious Web pages based on social trust was proposed.Besides the malicious URL list from third-party professional organizations,the direct and indirect trust ...
Xin LIU   +4 more
doaj   +2 more sources

k-fingerprinting: a Robust Scalable Website Fingerprinting Technique [PDF]

open access: yes, 2016
Website fingerprinting enables an attacker to infer which web page a client is browsing through encrypted or anonymized network connections. We present a new website fingerprinting technique based on random decision forests and evaluate performance over ...
Danezis, George, Hayes, Jamie
core   +1 more source

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

open access: yesAdvanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He   +10 more
wiley   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

open access: yesAdvanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang   +12 more
wiley   +1 more source

Dynamically insert the forest plot into a web page: The full Javascript codes [PDF]

open access: yesComputational Ecology and Software
In present study a method that enables users to dynamically insert the forest plot into a web page was presented. In this method, I created a Javascript module for generating and inserting a HTML table, including an entry function and two sub-functions ...
WenJun Zhang
doaj  

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

open access: yesAdvanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang   +10 more
wiley   +1 more source

WEB LOG EXPLORER – CONTROL OF MULTIDIMENSIONAL DYNAMICS OF WEB PAGES

open access: yesJournal of Information and Organizational Sciences, 2012
Demand markets dictate and pose increasingly more requirements to the supplymarket that are not easily satisfied. The supply market presenting its web pages to thedemand market should find the best and quickest ways to respond promptly to the ...
Mislav Šimunić   +2 more
doaj  

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