Results 251 to 260 of about 1,073,326 (316)

A hybrid extraction model for semantic knowledge discovery of water conservancy big data. [PDF]

PeerJ Comput Sci
Feng Y, Zhang F, Zhang Y, Dong J, Wang P.   +4 more
europepmc   +1 more source

Impact of C18 Epimerization of Indole‐ and Pyrazole‐Fused 18β‐Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies

ChemMedChem, EarlyView.
The indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
Ledy De‐la‐Cruz‐Martínez, Rosendo Martínez‐Arellano, Mitzi López‐Sánchez, José G. Alvarado‐Rodríguez, Jesús Martin Torres‐Valencia, David Equihua‐González, Julio‐César Almanza‐Pérez, Jaime Pérez‐Villanueva, Martín González‐Andrade, José C. Páez‐Franco, Francisco Cortés‐Benítez   +10 more
wiley   +1 more source

Bridging the knowledge gap: a feminist lens on the post-birth control syndrome and media narratives. [PDF]

Front Glob Womens Health
Niemann J, Führer A.
europepmc   +1 more source

BRWM: A relevance feedback mechanism for web page clustering

, 2006
Ioannis Anagnostopoulos, Christos‐Nikolaos Anagnostopoulos, Dimitrios D. Vergados, Ilias Maglogiannis   +3 more
openalex   +1 more source

Equivariant toric geometry and Euler–Maclaurin formulae

Communications on Pure and Applied Mathematics, EarlyView.
Abstract We first investigate torus‐equivariant motivic characteristic classes of toric varieties, and then apply them via the equivariant Riemann–Roch formalism to prove very general Euler–Maclaurin‐type formulae for full‐dimensional simple lattice polytopes.
Sylvain E. Cappell, Laurenţiu Maxim, Jörg Schürmann, Julius L. Shaneson   +3 more
wiley   +1 more source

A structured dataset of the federalist society's public engagements. [PDF]

F1000Res
Topaz CM.
europepmc   +1 more source

Operationalizing Decentralized Clinical Trials: Technology Insights from the Trials@Home RADIAL Proof‐of‐Concept Trial

Clinical Pharmacology &Therapeutics, EarlyView.
While decentralized clinical trials (DCTs) hold great promise for improving trial accessibility and efficiency, the effective deployment of DCT elements requires robust technological infrastructure and careful system integration. Although several innovative technologies are now available for implementing DCT elements, most existing setups integrate ...
Sten Hanke, Dimitrios Giannikopoulos, Bernhard Neumayer, Tea Vedenkannas, Robert Davey, Lampros Mpaltadoros, Brian Guthrie, Rebecca Jackson, Bart Lagerwaard, Mira Zuidgeest, on behalf of the Trials@Home consortium   +10 more
wiley   +1 more source

A comprehensive evaluation of life sciences data resources reveals significant accessibility barriers. [PDF]

Sci Rep
L'Yi S, Zhang HG, Mar AP, Smits TC, Weru L, Rojas S, Lex A, Gehlenborg N.   +7 more
europepmc   +1 more source

MetaOCaml server pages: Web publishing as staged computation

, 2006
Christopher League
openalex   +1 more source

Electronic Patient File‐Embedded Model‐Informed Precision Dosing Compared with Physician Dosing of Tacrolimus in Kidney Transplantation

Clinical Pharmacology &Therapeutics, EarlyView.
Model‐informed precision dosing (MIPD) of tacrolimus in renal allograft recipients, evaluated in silico, demonstrated improved (time to and) probability of target concentration attainment and smaller deviations from target range. Using simulated tacrolimus concentration‐time profiles, a study of 200 patients was predicted to have sufficient power to ...
Dirk R.J. Kuypers, Pieter Annaert, Borefore Jallah, Maarten Naesens, Maxine Teuns, Annouschka Laenen, Ruben Faelens   +6 more
wiley   +1 more source