Results 261 to 270 of about 2,686,138 (315)

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

InnORBIT’s web portal

The launch of the project’s website.
openaire   +1 more source

Unpacking the relationship between co‐creation and brand equity: A multi‐study approach

European Management Review, EarlyView.
Abstract Whilst some studies have shown that co‐creation positively influences brand equity, others have found only marginal or even negative effects, and several failure cases of co‐creation have been reported. To overcome the confusion generated by mixed findings, this paper unpacks the relationship between co‐creation and brand equity, considering ...
Stefan Markovic, Oriol Iglesias, Anna Torres, Pilar Rivera‐Torres, Nikolina Koporcic   +4 more
wiley   +1 more source

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomous effects in the B‐cell compartment

The FEBS Journal, EarlyView.
Ataxin‐1 is a polyglutamine protein associated with the etiology of spinocerebellar ataxia type 1 (SCA1) that has been recently found implicated in the risk of developing the autoimmune disorder multiple sclerosis (MS). Here, we took a conditional knockout approach to ablate ataxin‐1 exclusively in the B‐cell compartment and we found that this protein ...
Jonathan Jacob Carver, Rachael Riley Denbrock, Cindy Carolina Martines, Alessandro Didonna   +3 more
wiley   +1 more source

High Cost and Low Trust: Insights From Qualitative Commercial Fishing Cost Data in the Northeast United States

Fisheries Management and Ecology, EarlyView.
ABSTRACT In fisheries management, socioeconomic data, specifically qualitative data analysis, is often underutilized. This study qualitatively analyzed a primary federal data collection effort in the Northeast United States, The Greater Atlantic Region Commercial Fishing Business Cost Survey.
Elizabeth D. Conley, Samantha Werner, Gregory Ardini, Matthew Cutler, Patricia M. Clay   +4 more
wiley   +1 more source

Toward a global repository of insect traits (GRIT)

Insect Conservation and Diversity, EarlyView.
Biodiversity loss is accelerating, yet insect conservation is hindered by the absence of a centralised, comprehensive trait database. We propose the GRIT, a FAIR, open‐access platform uniting datasets and collaborators worldwide. GRIT will harness advanced computational tools for trait acquisition and imputation, enabling large‐scale ecological ...
Pedro Cardoso, Nathan Jay Baker, Mário Boieiro, Dries Bonte, Paulo A. V. Borges, Michael F. Braby, Vasco Branco, Dragan Chobanov, Luis Correia, Daniel T. Dalton, Mariana Damas‐Mora, Raphael K. Didham, Lynne Forster, Richard Glatz, Jacob A. Gorneau, Axel Hochkirch, Ameli Kirse, Elinor M. Lichtenberg, Nuria Macías‐Hernández, Marija Miličić, Melinda Moir, Pablo Moreno‐García, Ruth Neessen, Jorge Ari Noriega, Clint A. Penick, Kayla I. Perry, James Pryke, Carla Rego, Karl A. Roeder, Stéphanie Saussure, Vaughn Shirey, Pasi Sihvonen, Ilja Svetnik, Sergei Tarasov, Pedro Trindade, Ellen A. R. Welti, Mark Wong, Christoph Scherber   +37 more
wiley   +1 more source

Genetic Determinants of Peanut‐Specific IgG4 Levels in the Context of Sustained Oral Peanut Exposure in the LEAP Study

Immunology, EarlyView.
A cumulative genetic score based on IgG4‐associated variants explains a substantial proportion of variance in psIgG4 levels during sustained peanut consumption, highlighting strong gene‐by‐environment interactions. Our findings suggest that early, sustained peanut consumption, in combination with genetic factors, promotes a protective immune response ...
Kanika Kanchan, Karen Cerosaletti, James A. Perry, George DuToit, Monali Manohar, Hua Ling, Justin E. Paschall, Srinath Sanda, R. Sharon Chinthrajah, Gerald T. Nepom, Kari C. Nadeau, Stacie M. Jones, Gideon Lack, Ingo Ruczinski, Rasika A. Mathias   +14 more
wiley   +1 more source

Conference Web Portal

Conference Web ...
openaire   +1 more source

An Uncertainty Based Approach for Dealing With Selection Bias in Non‐Probability Samples

International Statistical Review, EarlyView.
Summary The main issue with non‐probability samples is that the standard design‐based approach cannot be applied as the selection mechanism is unknown. In this paper, the concept of uncertainty on data generating model, resulting from the lack of knowledge of the sampling design acting in the non‐probability sample, is discussed.
Pier Luigi Conti, Daniela Marella
wiley   +1 more source