Results 81 to 90 of about 130,504 (277)

HIC1 suppresses Tumor Progression and Enhances CD8+ T Cells Infiltration Through Promoting GSDMD‐induced Pyroptosis in Gastric Cancer

Advanced Science, EarlyView.
These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang, Wenqi Du, Lina Ding, Mengdi Wu, Dongsheng Pei   +4 more
wiley   +1 more source

Trustworthy Inverse Molecular Design via Alignment with Molecular Dynamics

Advanced Science, EarlyView.
Data‐driven inverse molecular design (IMD) is a promising approach to discovering new molecules with desired properties. Despite the remarkable progress, existing IMD methods lag behind in terms of trustworthiness, as indicated by their misalignment with the ground‐truth function that models the molecular dynamics.
Kevin Tirta Wijaya, Navid Ansari, Hans‐Peter Seidel, Vahid Babaei   +3 more
wiley   +1 more source

Cell fishing: A similarity based approach and machine learning strategy for multiple cell lines-compound sensitivity prediction.

PLoS ONE, 2019
The prediction of cell-lines sensitivity to a given set of compounds is a very important factor in the optimization of in-vitro assays. To date, the most common prediction strategies are based upon machine learning or other quantitative structure ...
E Tejera, I Carrera, Karina Jimenes-Vargas, V Armijos-Jaramillo, A Sánchez-Rodríguez, M Cruz-Monteagudo, Y Perez-Castillo   +6 more
doaj   +1 more source

Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa

Advanced Science, EarlyView.
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang, Xiaofei Wang, Chengli Liu, Kaixuan He, Xiu‐Li Hou, Haofei Luo, Shuaibin Zhang, Changqing You, Yajun Jia, Fuqiang Wang, Xianwei Song, Guodao Liu, Xian Deng, Xiaofeng Cao   +13 more
wiley   +1 more source

An Investigation of Term Weighting and Feature Selection Methods for Sentiment Analysis

Majlesi Journal of Electrical Engineering
Sentiment analysis automatically classifies the opinions, which are expressed in a document, usually as positive or negative. A review document in general, reflects its author’s opinion about the objects mentioned in the text.
Tuba Parlar, Selma Ayşe Özel
doaj  

deepTFBS: Improving within‐ and Cross‐Species Prediction of Transcription Factor Binding Using Deep Multi‐Task and Transfer Learning

Advanced Science, EarlyView.
DeepTFBS leverages deep learning to predict transcription factor binding sites across species, integrating multi‐task and transfer learning approaches to improve performance in data‐scarce scenarios. This study demonstrates enhanced accuracy in intra‐ and cross‐species prediction, revealing conserved regulatory patterns and functional variants.
Jingjing Zhai, Yuzhou Zhang, Chujun Zhang, Xiaotong Yin, Minggui Song, Chenglong Tang, Pengjun Ding, Zenglin Li, Chuang Ma   +8 more
wiley   +1 more source

Knowledge-based query system for the critical minerals

Applied Computing and Geosciences
Critical minerals are increasingly used in advanced, modern technologies. Exploration for these minerals require efficient mechanisms to search for the latest geological knowledge about the petrogenesis and spatial distribution of these essential ...
Armita Davarpanah, Hassan A. Babaie, W. Crawford Elliott   +2 more
doaj  

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

Advanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen, Xiaokang Ma, Longlin Zhang, Hao Li, Jichang Zheng, Shengru Wu, Ke Zuo, Yulong Yin, Jing Wang, Bie Tan   +9 more
wiley   +1 more source

Robust image classification system via cloud computing, aligned multimodal embeddings, centroids and neighbours

Machine Learning with Applications
We propose a framework for a cloud-based application of an image classification system that is highly accessible, maintains data confidentiality, and robust to incorrect training labels. The end-to-end system is implemented using Amazon Web Services (AWS)
Wei Lun Koh, James Boon Yong Koh, Bing Tian Dai   +2 more
doaj  

Advancing Soil Organic Carbon Prediction: A Comprehensive Review of Technologies, AI, Process‐Based and Hybrid Modelling Approaches

Advanced Science, EarlyView.
This review highlights advances in soil organic carbon (SOC) quantification using remote sensing, proximal soil sensing, AI (ML and DL), and biogeochemical modelling. Integrating diverse data sources and models improves SOC prediction accuracy. Key priorities include enhancing data availability, refining models, incorporating microbial processes, and ...
Zijuan Ding, Ke Liu, Sabine Grunwald, Pete Smith, Philippe Ciais, Bin Wang, Alexandre M.J.‐C. Wadoux, Carla Ferreira, Senani Karunaratne, Narasinha Shurpali, Xiaogang Yin, Dale Roberts, Oli Madgett, Sam Duncan, Meixue Zhou, Zhangyong Liu, Matthew Tom Harrison   +16 more
wiley   +1 more source