Results 211 to 220 of about 532,216 (314)

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

open access: yesAdvanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang   +7 more
wiley   +1 more source

Web Search Trends of Implementing the Patient Autonomy Act in Taiwan. [PDF]

open access: yesHealthcare (Basel), 2020
Yang PC   +8 more
europepmc   +1 more source

A High‐Entropy Strategy for Chemoresistive Ethanol Sensors With Remarkably Rapid and Selective Response

open access: yesAdvanced Science, EarlyView.
The configurational‐entropy strategy enables rapid and sensitive ethanol detection using a multicomponent oxide. The high‐entropy (InSnFeZnW)Ox provides enriched oxygen vacancies and diverse adsorption sites that strengthen surface reactivity. The sensor achieves a 5135% ethanol response with fast kinetics and stable long‐term operation.
Gi Baek Nam   +19 more
wiley   +1 more source

Dilemmas of nomenclature: Web search analysis reveals European preferences in atopic skin diseases. [PDF]

open access: yesClin Transl Allergy
Wecker H   +13 more
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang   +9 more
wiley   +1 more source

Using A Google Web Search Analysis to Assess the Utility of ChatGPT in Stem Cell Therapy. [PDF]

open access: yesStem Cells Transl Med
Chen L   +7 more
europepmc   +1 more source

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

open access: yesAdvanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen   +15 more
wiley   +1 more source

Interpretable Machine Learning Framework for Nb─Si Based Alloy Design with Enhanced Fracture Toughness

open access: yesAdvanced Science, EarlyView.
An interpretable machine learning framework integrating SHAP and PDP analysis identifies critical design descriptors from 139 physicochemical features for Nb─Si alloys. The framework achieves <7% prediction error and guides the discovery of Nb38.5Ti38.5Si3Zr18V2 alloy with 22.791 MPa·m1/2 fracture toughness, breaking the 20 MPa·m1/2 barrier.
Dezhi Chen   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy