Results 271 to 280 of about 2,006,269 (325)

Design of a Parallel and Distributed Web Search Engine

, 2004
Salvatore Orlando, Raffaele Perego, Fabrizio Silvestri   +2 more
openalex   +2 more sources

Aloe‐Emodin Targeting FOXC2 Disrupts NETs Formation and EMT‐Driven Postoperative Peritoneal Adhesion Through TGF‐β1‐Smad2/3 Pathway

Advanced Science, EarlyView.
Forkhead box protein C2 (FOXC2) is highlighted as a pivotal effector in postoperative peritoneal adhesion (PPA) formation. Mechanically, FOXC2 mediates NETs‐induced EMT alterations through the TGF‐β1‐Smad2/3 pathway. Aloe‐emodin (AE) ameliorates FOXC2‐driven fibrosis by blocking NETs formation and EMT changes through this pathway.
Lili Yang, Yunda Fang, Yuheng Lian, Ziyang Kong, Jia Miao, Yanqi Chen, Wen Li, Feiyan Chen, Bin Zhang, Yao Chen, Yaoyao Bian   +10 more
wiley   +1 more source

Rethinking the AI Paradigm for Solubility Prediction of Drug‑Like Compounds with Dual‐Perspective Modeling and Experimental Validation

Advanced Science, EarlyView.
Aqueous solubility governs drug delivery and bioavailability, yet its prediction remains challenging. Utilizing the largest curated dataset of drug‐like molecules, prediction models are constructed through dual‐perspective benchmarking. Stacking methods outperform advanced deep learning due to data constraints. These validated models enabled systematic
Qilin Zhu, Yuxin Qiu, Guzhong Chen, Wenyao Chen, Xiang Zhang, Zhiwen Qi, Xuezhi Duan, De Chen, Zhen Song   +8 more
wiley   +1 more source

Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High‐Throughput Sequencing Data Mining

Advanced Science, EarlyView.
Analysis of 57 536 high‐throughput sequencing datasets uncovers a vast, hidden world of viruses in wildlife. The researchers reveal significant geographic and host‐specific patterns of viruses, and their surprising cross‐species transmissions, such as avian flu viruses infecting goats.
Hai Wang, Yafei Meng, Xiaoyuan Chen, Xinyuan Cui, Qian Zuo, Na Han, Xianghui Liang, Xuejuan Shen, Caiwu Li, Desheng Li, Fumin Wang, Liangping He, Rujian Chen, Xingbang Lu, Wenjie You, Aiping Wu, Rui‐Ai Chen, Wu Chen, Chan Ding, Yongyi Shen   +19 more
wiley   +1 more source

Dendronized Encapsulation with Hierarchical Rigidification Enabling Robust Solution Room‐Temperature Phosphorescence, Efficient Electroluminescence and Ultralong Afterglow

Advanced Science, EarlyView.
The organic RTP's rigidity‐flexibility conflict via multiscale confinement is resolved. Dendronized donor‐acceptor with alkyl carbazoles enables intramolecular encapsulation and stability of triplet excitons, achieving 9 ms solution RTP. Combined with aggregation/PMMA doping, this suppresses nonradiative decay, achieving 72% film PLQY/17.2% OLED EQE ...
Chensen Li, Zhenchen Lou, Lianrui Hu, Guohua Xie, Song Zhang, Bo Xu, Zheng Zhao, Jacky W. Y. Lam, Ben Zhong Tang   +8 more
wiley   +1 more source

Ultra‐Robust Conductive Hydrogels Enabled by a Gradient Bond‐Breaking Pseudo‐Drying Strategy

Advanced Science, EarlyView.
A bioinspired PVA‐ANFs hydrogel, engineered via novel gradient bond‐breaking, achieves unprecedented mechanical performance: ultrahigh strength (≈18 MPa), modulus (≈12 MPa), toughness (≈74 MJ/m3), and record fracture energy (≈269 kJ m−2). It exhibits cryogenic flexibility (−70°C), high ionic conductivity (936.3 mS m−1), and biocompatibility.
Dongchao Ji, Hongyang Han, Jiajun Li, Xiaoman Fei, Xiaolei Wang, Zhuochao Wang, Tao Song, Lei Yang, Zhibo Zhang, Wenxin Cao, Jiecai Han, Jiaqi Zhu   +11 more
wiley   +1 more source

Design Principles for Deployable Fibers Inspired by Hagfish Defense

Advanced Science, EarlyView.
Hagfish slime deploys fibers from coiled skeins to form an ultra‐dilute, water‐trapping network. Inspired by this mechanism, design principles are established for synthetic skeins, fabricated with tightly coiled fibers that unravel under flow. These synthetic skeins demonstrate deployable fibrous networks, highlighting generalizable strategies for ...
Mohammad Tanver Hossain, Wonsik Eom, Pallab Layak, Jeongmin Kim, Carolyn Darling, Andrew Lowe, Douglas S. Fudge, Sameh H. Tawfick, Randy H. Ewoldt   +8 more
wiley   +1 more source

Superconductivity in Hourglass Dirac Chain Metals (Ti, Hf)IrGe

Advanced Science, EarlyView.
We report the discovery of ternary germanide superconductors MIrGe (M = Ti, Hf) that host hourglass Dirac chains protected by nonsymmorphic symmetry. These compounds exhibit bulk type‐II superconductivity with fully gapped states and preserved time‐reversal symmetry, as confirmed by µSR measurements.
Pavan Kumar Meena, Dibyendu Samanta, Sonika Jangid, Roshan Kumar Kushwaha, Rhea Stewart, Adrian D. Hillier, Sudeep Kumar Ghosh, Ravi Prakash Singh   +7 more
wiley   +1 more source