Results 131 to 140 of about 341,640 (282)

NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis

open access: yesAdvanced Science, EarlyView.
NPR1 induces lipolysis of stored lipid droplet and enhances mitochondrial oxidative phosphorylation to fuel gastric cancer metastasis. Specifically, NPR1‐mediated activation of PKG directly phosphorylates and activates HSL at Ser855 and Ser951, thereby driving lipolytic processes.
Huafeng Fu   +15 more
wiley   +1 more source

EBI Search: providing discovery tools for biological metadata in 2025. [PDF]

open access: yesNucleic Acids Res
Pearce M   +6 more
europepmc   +1 more source

A Multi‐Property Optimizing Generative Adversarial Network for de novo Antimicrobial Peptide Design

open access: yesAdvanced Science, EarlyView.
A Multi‐Property Optimizing Generative Adversarial Network (MPOGAN) is proposed to iteratively learn the relationship between peptides and multiple properties using a dynamically dataset. As the quality of the dataset improves, MPOGAN's ability to design antimicrobial peptides (AMPs) with multiple desired properties is enhanced.
Jiaming Liu   +16 more
wiley   +1 more source

Online peer support for people with dementia: a scoping review protocol. [PDF]

open access: yesJBI Evid Synth
Loseto-Gerritzen EV   +5 more
europepmc   +1 more source

RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics

open access: yesAdvanced Science, EarlyView.
RAB5A‐mediated unjamming enhances active wetting through distinct biomechanical processes: a) upregulation of specific integrin subunits, enhanced focal adhesions kinetics and activity; b) supracellular organization relying on nanoscale integrin clustering, and the formation of a stiff and collective actin cable; and c) softening of the spheroid core ...
Grégoire Lemahieu   +19 more
wiley   +1 more source

L2S2: chemical perturbation and CRISPR KO LINCS L1000 signature search engine. [PDF]

open access: yesNucleic Acids Res
Marino GB   +3 more
europepmc   +1 more source

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