Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction
Advanced Science, EarlyView.This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma +11 more
wiley +1 more source
Characterizing interdisciplinarity of researchers and research topics using web search engines. [PDF]
PLoS One, 2012 Sayama H, Akaishi J.
europepmc +1 more source
Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages
Advanced Science, EarlyView.Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu +14 more
wiley +1 more source
Análisis de consultas a un buscador y su aplicación a la jerarquización de páginas web
BiD: Textos Universitaris de Biblioteconomia i Documentació, 2003 Existen diversas fuentes de información en la web. Una de ellas es la información que deja el usuario mientras usa un buscador. Es posible utilizar esta información para complementar el resultado de algoritmos de jerarquización tradicionales, de manera ...
Baeza-Yates, Ricardo, Saint-Jean, Felipe
doaj
Timestamp-based result cache invalidation for web search engines
, 2011 Şadiye Alıcı +4 more
openalex +2 more sources
Advanced Science, EarlyView.This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun +12 more
wiley +1 more source
Exploiting query views for static index pruning in web search engines
, 2009 İsmail Sengör Altıngövde +2 more
openalex +2 more sources
Integrating Databases, Search Engines and Web Applications: A Model-Driven Approach [PDF]
, 2007 Alessandro Bozzon +3 more
openalex +1 more source
Strong Proton‐Phonon Coupling Drives Fast Ion Transport in Perovskites
Advanced Science, EarlyView.Experimental and computational phonon analysis of ABO3‐type proton conductor BaSnO3 shows that substitution on the B‐site with yttrium forms an imaginary phonon mode which is instrumental for the function as proton conductor. This overcompensates the adverse proton trapping effect of the yttrium.
Alexey Rulev +8 more
wiley +1 more source
Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier
Advanced Science, EarlyView.SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao +11 more
wiley +1 more source