Results 61 to 70 of about 2,169,107 (354)
Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source
Toward discovering and exploiting private server-side Web API
网络与信息安全学报, 2016 Most of the interfaces for mobile application and server interaction use the Web API for communication,but the Web API introduced by these mobile applications may introduce new security issues.To facilitate the study of the security of Web API,a system ...
Jia CHEN, Shan-qing GUO
doaj +3 more sources
FEBS Open Bio, EarlyView.Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley +1 more source
SIFT web server: predicting effects of amino acid substitutions on proteins
Nucleic Acids Res., 2012 The Sorting Intolerant from Tolerant (SIFT) algorithm predicts the effect of coding variants on protein function. It was first introduced in 2001, with a corresponding website that provides users with predictions on their variants.
Ngak-Leng Sim +5 more
semanticscholar +1 more source
Most autophagic cell death studies lack evidence of causality
FEBS Open Bio, EarlyView.Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley +1 more source
SHAPER: A Web Server for Fast and Accurate SHAPE Reactivity Prediction
Frontiers in Molecular Biosciences, 2021 Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) chemical probing serves as a convenient and efficient experiment technique for providing information about RNA local flexibility.
Yuanzhe Zhou +5 more
doaj +1 more source
PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data
Database J. Biol. Databases Curation, 2019 Single-cell RNA sequencing is an increasingly used method to measure gene expression at the single cell level and build cell-type atlases of tissues. Hundreds of single-cell sequencing datasets have already been published. However, studies are frequently
Oscar Franzén, L. Gan, J. Björkegren
semanticscholar +1 more source
DupliPHY-Web: a web server for DupliPHY and DupliPHY-ML [PDF]
Bioinformatics, 2014 Abstract Summary : Gene duplication and loss are important processes in the evolution of gene families. Moreover, growth of families by duplication and retention is an important mechanism by which organisms gain new functions. Therefore the ability to infer the evolutionary histories of families is an important step in understanding the ...
Ames, R M, Lovell, S C
openaire +4 more sources
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT This manuscript describes the intentional use of adult learning principles in creating three faculty development initiatives centering on equity‐based teaching. The authors reflected on the design and development process, facilitation and the perceived benefits and challenges.
Kayon Murray‐Johnson +1 more
wiley +1 more source
TBI server: a web server for predicting ion effects in RNA folding. [PDF]
PLoS ONE, 2015 Metal ions play a critical role in the stabilization of RNA structures. Therefore, accurate prediction of the ion effects in RNA folding can have a far-reaching impact on our understanding of RNA structure and function. Multivalent ions, especially Mg²⁺,
Yuhong Zhu, Zhaojian He, Shi-Jie Chen
doaj +1 more source