ABSTRACT Introduction Adolescent siblings of children with cancer are at elevated risk for psychosocial problems. Unfortunately, various barriers such as limited family time and resources, conflicting schedules, and psychosocial staffing constraints at cancer centers hinder sibling access to support.
Christina M. Amaro +10 more
wiley +1 more source
OpenedEyes: A web standards-based generic framework for multidimensional information visualization
Nenhum resumo ...
Caio Sacramento de Britto Almeida +1 more
doaj +1 more source
SEARCH AND ORCHESTRATION OF DATA AND PROCESSES IN A FEDERATED ENVIRONMENT [PDF]
This paper describes on-going research on streamlining the access and use of spatial data and processes in Australia. Spatial data in Australia is available on-line at many levels of government from local authorities, state and territories (jurisdictions)
J. Siao Him Fa +6 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Intelligent Information Retrieval Needs Smart Tools and Supporting Standards
Though Google is an eff ective and popular search engine for locating information on the World Wide Web, it has tended to have the eff ect of blinding people to the enormous and growing problem of accessing and sharing digital information, much of which ...
Alan Gilchrist
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Developing a tool for resolving standard discrepancies using large language models [PDF]
This paper presents a useful tool leveraging Large Language Models (LLM) to resolve discrepancies between corporate and national standards. Firstly, we introduce a Food Standard Dataset comprising 1420 Chinese national standards and 100 corporate ...
Li Lei, Duan Manni, Wang Yongheng
doaj +1 more source
Twinbase: Open-Source Server Software for the Digital Twin Web
Digital twins are expected to form a network, a “Digital Twin Web,” in the future. Digital Twin Web follows a similar structure to the World Wide Web and consists of meta-level digital twins that are described as digital twin description ...
Juuso Autiosalo +2 more
doaj +1 more source

