Results 51 to 60 of about 315,014 (312)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Selection Bias in Web Surveys [PDF]
International Statistical Review, 2010 Summary At first sight, web surveys seem to be an interesting and attractive means of data collection. They provide simple, cheap, and fast access to a large group of potential respondents. However, web surveys are not without methodological problems.
openaire +4 more sources
Continuous Household Survey, 1987
, 1995 copyright UK Data Service and data collection copyright owner.The Continuous Household Survey (CHS) is one of the largest continuous surveys carried out in Northern Ireland.
Policy Planning and Research Unit (Northern Ireland), Central Survey Unit
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Continuous Household Survey, 1983
, 2004 copyright UK Data Service and data collection copyright owner.The Continuous Household Survey (CHS) is one of the largest continuous surveys carried out in Northern Ireland.
Policy Planning and Research Unit (Northern Ireland), Central Survey Unit
core +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Chinese Academic Library Services: A Web Survey
International Journal of Librarianship, 2016 Chinese students form a significant population on Canadian university campuses. Literature indicates that these students face various challenges when using library services to meet their information needs.
Guoying Liu
doaj +1 more source
Folksonomies, the semantic web, and movie recommendation [PDF]
, 2007 While the Semantic Web has evolved to support the meaningful exchange ofheterogeneous data through shared and controlled conceptualisations, Web 2.0 has demonstrated that large-scale community tagging sites can enrich the semantic web with readily ...
C. CATTUTO +13 more
core
Continuous Household Survey, 1986
, 1995 copyright UK Data Service and data collection copyright owner.The Continuous Household Survey (CHS) is one of the largest continuous surveys carried out in Northern Ireland.
Policy Planning and Research Unit (Northern Ireland), Central Survey Unit
core +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source