In this study, ferroptosis in colorectal cancer cells is induced by FK866 through the NAD⁺/STAT3/GPX4 pathway. To minimize systemic toxicity, a reactive oxygen species (ROS)‐responsive hydrogel is developed to co‐deliver FK866 and C188‐9, resulting in synergistic and localized antitumor effects.
Chenyang Ye+14 more
wiley +1 more source
Multimodal Locomotion: Next Generation Aerial–Terrestrial Mobile Robotics
Aerial–terrestrial robots can achieve efficient energy consumption and robust environmental interaction by adding morphological features, adapting forms for locomotion transitions, and integrating multiple platforms. This next generation of mobile robots advances real‐world robotic deployment for operations with complex tasks and tackle environments ...
Jane Pauline Ramirez, Salua Hamaza
wiley +1 more source
Complementary Effect of an Educational Website for Children and Adolescents with Primary Headaches in Tertiary Care: A Randomized Controlled Trial. [PDF]
Goldstein H+3 more
europepmc +1 more source
S12.02 Setting up the royal college of psychiatrists' website [PDF]
Dave Jago
openalex +1 more source
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo+10 more
wiley +1 more source
Co-creating and disseminating substance use and vaping educational videos, question prompt lists, and other resources in partnership with community organizations and youth in Western North Carolina. [PDF]
Sleath B+10 more
europepmc +1 more source
Evaluating Website Modifications at the National Library of Medicine through Search Log Analysis
Aaron Redalen, Naomi Miller
openalex +1 more source
The present study reveals that PLAUR+ neutrophils are enriched in immunotherapy non‐responders and correlate with poor prognosis. PLAUR+ neutrophils dictate immunotherapy resistance in hepatocellular carcinoma by forming an immunosuppressive tumor microenvironment characterized by CD8+ T cell exclusion and macrophage‐dependent immune suppression.
Shaoqing Liu+11 more
wiley +1 more source
Spine Surgery Fellowships in Mexico: Web Content and Accessibility. [PDF]
Aguilar-Chavez F+6 more
europepmc +1 more source
Anthocyanins Prevent Mastitis Exacerbation by Inhibiting PANoptosis Activation
PANoptosis activation is an effective therapeutic target during mastitis progression, and Gasdermin D activation is key factor contributing to blood milk barrier damage during mastitis, while cyanidin 3‐O‐galactoside can inhibit these targets to exert a protective effect. Therefore, the extraction of key active ingredients from plants for the treatment
Rui Feng+23 more
wiley +1 more source