Advanced Science, EarlyView.Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du +9 more
wiley +1 more source
A qualitative exploration of the barriers and facilitators for engagement with a self-led biopsychosocial support tool, Pain Rehabilitation to Optimize Major Orthopaedic Trauma REcovery (PROMOTE), for patients with complex lower-limb orthopaedic trauma. [PDF]
Bone Jt OpenFordham B +6 more
europepmc +1 more source
Advanced Science, EarlyView.SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley +1 more source
CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning
Advanced Science, EarlyView.CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang +11 more
wiley +1 more source
A critical analysis of online social support websites for Australians seeking bariatric surgery. [PDF]
Aust J PsycholStewart R, Chur-Hansen A.
europepmc +1 more source
Advanced Energy Materials, EarlyView.This review provides a bottom‐up evaluation of sodium‐ion battery safety, linking material degradation mechanisms, cell engineering parameters, and module/pack assembly. It emphasizes that understanding intrinsic material stability and establishing coordinated engineering control across hierarchical levels are vital for preventing degradation coupling ...
Won‐Gwang Lim +5 more
wiley +1 more source
Development and Evaluation of a German Suicide Prevention Website for Men: Exploratory Study. [PDF]
JMIR Form ResSpahn C +3 more
europepmc +1 more source
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT Estimates of reductions in greenhouse gas (GHG) emissions from lower demand for cattle‐based products must account for substitution effects. This study collected data through two surveys—one on ground beef and another on dairy milk—to evaluate substitution effects and potential GHG reductions.
Brandon R. McFadden +5 more
wiley +1 more source
From patients to partners: evaluating a co-designed website for congenital hypogonadotropic hypogonadism. [PDF]
Endocr ConnectDwyer AA +6 more
europepmc +1 more source
Temperature Sensitivity and Adaptation of Cereal Yields: Empirical Evidence From Italy
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT This paper investigates the evolving temperature sensitivity and climate adaptation of cereal yields in Italy from 1952 to 2023, using province‐level data for maize, common wheat, and durum wheat. Employing panel data econometric methods, we estimate yield responses to heat exposure, changes in sensitivity over time, and adaptation to climate ...
Paolo Nota +2 more
wiley +1 more source