Results 101 to 110 of about 95,019 (268)

Applying the Skip Navigation Links in the Context of the Websites’ Accessibility of Central Public Administration Bodies in the Prešov Region [PDF]

open access: yesSocietas et Iurisprudentia, 2016
The study focuses in its main aim on seeking yet undetected or undefined deficits in relation to applying the skip navigation mechanism on the websites of the central public administration bodies in the Prešov Region in the context of improving the ...
Jana Koprlová
doaj  

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

open access: yesAdvanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

EVALUATING ACCESSIBILITY OF MALAYSIAN PUBLIC UNIVERSITIES WEBSITES USING ACHECKER AND WAVE

open access: yesJournal of ICT, 2016
Websites become essential means for most universities to communicate, exchange of relevant information and enable transactions among their stakeholders. Therefore, website accessibility accessible website is crucial to students to ensure equal access to ...
Aidi Ahmi, Rosli Mohamad
doaj  

Genome‐Wide Silencer Screening Reveals Key Silencer Modulating Reprogramming Efficiency in Mouse Induced Pluripotent Stem Cells

open access: yesAdvanced Science, EarlyView.
This study utilized Ss‐STARR‐seq to construct a genome‐wide silencer map of mouse cells and elucidated the fundamental characteristics of these silencers. These silencers exist in a cell‐specific manner and exhibit unique epigenetic modifications. Through functional experiments, we also discovered that these silencers can regulate gene expression and ...
Xiusheng Zhu   +12 more
wiley   +1 more source

ACCESS: Prompt Engineering for Automated Web Accessibility Violation Corrections [PDF]

open access: yesarXiv
With the increasing need for inclusive and user-friendly technology, web accessibility is crucial to ensuring equal access to online content for individuals with disabilities, including visual, auditory, cognitive, or motor impairments. Despite the existence of accessibility guidelines and standards such as Web Content Accessibility Guidelines (WCAG ...
arxiv  

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

open access: yesAdvanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng   +11 more
wiley   +1 more source

Inhibition of Aberrant Activated Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism

open access: yesAdvanced Science, EarlyView.
LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su   +17 more
wiley   +1 more source

Dynamics of Cell Fate Decisions during Chemically Induced Multi‐Lineage Trans‐Differentiation at Single‐Cell Level

open access: yesAdvanced Science, EarlyView.
A critical aspect of chromosomal remodeling in small molecule‐induced multilineage trans‐differentiation(iMT) is elucidated. A dynamic atlas spanning over 35 days profiles terminal trans‐differentiated cells, which reverted to a more youthful state. This study reveals parallels between iMT and other cell fate determination processes, emphasizing an ...
Weigao E   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy