Results 131 to 140 of about 29,236 (264)

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Evaluating the Readability, Accessibility, and Quality of Online Health Information on Opioid Use Disorder: A Comparative Analysis of Government and Non-Government Websites. [PDF]

Adv Health Inf Sci Pract
Ahmed FZ, Noblin A, Courtelyou K, Tynes G.   +3 more
europepmc   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Public-Facing Communication of Health and Social Services for Older Adults and Their Family or Friend Caregivers: Environmental Scan of 58 Integrated Care Teams' Websites in Ontario, Canada. [PDF]

JMIR Aging
Nguyen H, Corbett K, Vervaecke D, Ivanovski N, Shirazi S, Yadollahi S, Shrestha HL, Slavescu I, Zarandi Baghini B, Medvedyuk S, Hoben M.   +10 more
europepmc   +1 more source

ADAPTIVE WEBSITE RENDERING BASED ON ACCESSIBILITY PROFILES: BROWSER EXTENSION MODEL AND ARCHITECTURE

Veronika Luhovska, Vasyl Lyashkevych
openalex   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Women's Engagement With Different Internet-Enabled Technologies to Access Digital Menopause Information: Mixed Methods, Multiphase Sequential Study. [PDF]

J Med Internet Res
Osborne AK, Sillence E, Claisse C, Durrant AC.   +3 more
europepmc   +1 more source

Website Provision of Accessibility Information By New Zealand Luxury Lodges: A Luxury for People With Disabilities?

, 2023
Brielle Gillovic, Tracy-Lesley Harkison
openalex   +1 more source

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

Quality and Usability Evaluation of U.S. Clinical Informatics Fellowship Websites. [PDF]

Appl Clin Inform
You JG, Yuan J, Gupta G, Mitragotri S, Shannon K, Hassan A, Goff A, He S, Kim E.   +8 more
europepmc   +1 more source