Results 51 to 60 of about 199,840 (302)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

21. Applying Universal Instructional Design to Course Websites by Using Course Evaluations

open access: yesCollected Essays on Learning and Teaching, 2012
The authors explore their use of learner-centred teaching strategies and Universal Instructional Design (UID) on course websites. UID is based on universal design, the design of products and environments intended to be usable by all people to the ...
Irene Carter, Donald Leslie, Denise Kwan
doaj   +1 more source

Study on Chinese Tourism Web Sites' Distribution and Online Marketing Effects. [PDF]

open access: yes, 2010
As a platform and carrier of tourism information, tourism websites (TWs) and online tourism marketing have deeply affected the tourism industry. The authors adopt a geographical perspective to analyze the distribution of Chinese tourism websites (CTWs ...
Baggio R.   +21 more
core   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Rural small firms' website quality in transition and market economies [PDF]

open access: yes, 2013
Purpose – The purpose of this paper is to investigate website quality in rural firms in four countries, by using Gonzalez and Palacios's Web Assessment Index (WAI).
Galloway, Laura, Sanders, John William
core   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

open access: yesFEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

A quantitative approach to evaluate usability of academic websites based on human perc

open access: yesEgyptian Informatics Journal, 2014
In this competitive world, websites are considered to be a key aspect of any organization’s competitiveness. In addition to visual esthetics, usability of a website is a strong determinant for user’s satisfaction and pleasure.
Sharmistha Roy   +2 more
doaj   +1 more source

Public health careers: mapping information, informing practitioner needs [PDF]

open access: yes, 2016
Public health promotion and ill health prevention is a key priority for the NHS. The public health workforce is central to achieving improved health outcomes for a diverse and changing population.
Binding, Charlene   +2 more
core   +1 more source

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