Results 91 to 100 of about 287,450 (302)

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

The evidence base for careers websites. What works? [PDF]

, 2017
There is some evidence which suggests that using career websites as part of broader careers education provision can impact positively on young people’s career readiness and the quality and diversity of their social networks for careers purposes.
Everitt, Julia, Staunton, Tom, Vigurs, Katy   +2 more
core  

Collaborative Learning for Children with Special Needs through Computer Supported Collaborative Learning at Vocational High Schools

Jurnal Pendidikan Teknologi dan Kejuruan, 2017
The objectives of this study were to determine how to apply collaborative learning model through a Computer Supported Collaborative Learning (CSCL) approach for disabled students in vocational schools.
Hendra Jaya, Sapto Haryoko, Lu’mu Lu’mu   +2 more
doaj   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

The Role of Hypertext in Consumer Decision Making. The Case of Travel Destination Choice

Journal of Entrepreneurship, Management and Innovation, 2012
Travel is one of the most popular items people tend to be comfortable with purchasing over the Internet. Hypertext is a form of electronic text composed of blocks of words (or images) linked electronically by multiple paths, chains, or trails. This study
Raúl Valdez Munoz
doaj   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Canadian medical tourism companies that have exited the marketplace: Content analysis of websites used to market transnational medical travel

Globalization and Health, 2011
Background Medical tourism companies play an important role in promoting transnational medical travel for elective, out-of-pocket medical procedures. Though researchers are paying increasing attention to the global phenomenon of medical tourism, to date ...
Turner Leigh
doaj   +1 more source

WEBSITE OF THE WEEK

BMJ, 1999
The Female Genital Mutilation Homepage www.fgmnetwork.org At this very moment about 8to 10million women and girls in the Middle East and in Africa are at risk of undergoing one form or another of genital mutilation. Even though there is increasing awareness for this topic, we may not realise the magnitude of this problem: the number of affected women ...
openaire   +3 more sources

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Usabilidade de interfaces em websites envolvendo animações, propagandas e formas de auxílio [PDF]

, 2002
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.A quantidade de websites vem aumentando rápida e diariamente, no entanto, questões envolvendo a usabilidade deles ...
Kulczynskyj, Michael
core