Results 41 to 50 of about 256,079 (316)

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Investigating casino event management integration: The case of East and South Asia casinos [PDF]

Journal of Tourism, Heritage & Services Marketing, 2017
The aim of this study is to investigate the gap of event management in East and South Asia’s casinos throughout the information provided by casinos on their websites. Main objective is to identify the differences and similarities of event holding in East
Tzu-Wei (Arwen) Huang, Wan-Yu (Quentina) Tseng, Jing-Yao (Jerry) Lin, Ching-Xiong (Dennis) Tay   +3 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Website Modeling and Website Generation [PDF]

, 2004
Websites become more often based on data warehouse architectures. Our group uses the website modeling language SiteLang [TD01]. This language has reached a maturity that allows simple application and goes far beyond what other approaches can handle: It is powerful, consistent, has a well-developed theory fundament [Tha00a,Tha00b], does not allow to ...
Irina Romalis, Klaus-Dieter Schewe, Bernhard Thalheim, Thomas Raak, Gunar Fiedler   +4 more
openaire   +2 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Pelatihan Pembuatan Media Pembelajaran Berbasis Website Terintegrasi Model Pembelajaran Project Based Learning bagi Guru SMAN 2 Tondano Minahasa

Jurnal Pengabdian UNDIKMA, 2023
This community service aims to increase knowledge and competence in creating website-based learning media integrated with the project-based learning (PjBL) learning model for teachers at SMAN 2 Tondano, Minahasa Regency.
Kamaruddin Kamaruddin, Patricia Mardiana Silangen, Djeli Alvi Tulandi   +2 more
doaj   +1 more source

Measuring and Modeling the Free Content Web [PDF]

arXiv, 2023
Free content websites that provide free books, music, games, movies, etc., have existed on the Internet for many years. While it is a common belief that such websites might be different from premium websites providing the same content types, an analysis that supports this belief is lacking in the literature.
arxiv  

Construindo a accountability em portais eletrônicos de câmaras municipais: um estudo de caso em Santa Catarina

Cadernos EBAPE.BR
O portal eletrônico é considerado uma tecnologia capaz de possibilitar condições para a construção da accountability dos atos públicos. Contudo, a confirmação da utilização do portal eletrônico com esse propósito carece de pesquisas empíricas ...
Fabiano Maury Raupp, José Antonio Gomes de Pinho   +1 more
doaj   +1 more source