Results 181 to 190 of about 417,611 (276)

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Varieties of Economic Elites? Preliminary Results From the World Elite Database (WED). [PDF]

Br J Sociol
Bühlmann F, Christesen CA, Cousin B, Denord F, Ellersgaard CH, Lagneau-Ymonet P, Larsen AG, Savage M, Thine S, Young K, Araujo P, Arrigoni P, Atria J, Benz P, Behr J, Botelho MDC, Butt A, Casanova P, Clemente-Casinhas L, Castellani A, Cescon F, Dagnes J, Debska H, Delval AS, Dragun V, Egas A, Emilsson K, Fan X, Fu F, Gentile J, Gomes O, Gronwald V, Heredia M, Hjellbrekke J, Honório J, Huang J, Inkley J, Johansson H, Koiranen I, Koivula A, Kuusela H, Levita G, Ling C, Lu P, Lukas M, Lunding J, Mahmoudzadeh M, McQuade S, Méndez ML, Nunes N, O'Brien S, Otero G, Pagnini M, Pelfini A, Pereira J, Roa C, Rossier T, Saga ML, Santana D, Schneickert C, Schimpfössl E, Schoenberger F, Solipa I, Trembaczowski Ł, Toft M, Vale S, Vasconcelos P, Velazco JQ, Warczok T, Yu X.   +69 more
europepmc   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Numerical Investigation of Drop Impact on Immiscible Liquid-Liquid Interfaces. [PDF]

ACS Omega
Liao B, Ji W, Bu Y, Du W, Chen S.
europepmc   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Serotonin selectively modulates visual responses of object motion detectors in <i>Drosophila</i>. [PDF]

J Neurophysiol
Bertsch DJ, Palacios Castillo LM, Frye MA.   +2 more
europepmc   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

A dataset on the use of online video by students at the in-video level. [PDF]

Data Brief
Córcoles C, Rodríguez GC, Guerrero-Roldán AE, Huertas MA.   +3 more
europepmc   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Conformational changes induced by K949A mutation in the CRISPR-Cas12a complex drives an effective target-binding mechanism. [PDF]

Curr Res Struct Biol
Kesarwani P, Sundar D.
europepmc   +1 more source